HLA-DPβ and susceptibility to multiple sclerosis: An analysis of caucasoid and Japanese patient populations

Ann B. Begovich, Rhea C. Helmuth, Jorge R. Oksenberg, Koichiro Sakai, Takeshi Tabira, Takehiko Sasazuki, Lawrence Steinman, Henry A. Erlich

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Abstract

Nonradioactive sequence-specific oligonucleotide (SSO) probes specific for the HLA-DPβ locus have been used in a simple dot-blot assay to DPβ-type samples amplified by the polymerase chain reaction (pcr) from Caucasoid (n = 24) and Japanese (n = 23) patients with multiple sclerosis (ms) as well as ethnically matched controls. In contrast to previous reports, no DPβ allele was found to be increased in either patient population. However, the results do show a dramatic difference in the allele frequencies between the two control populations, further emphasizing the need for ethnically matched controls in studies of HLA and disease.

Original languageEnglish
Pages (from-to)365-372
Number of pages8
JournalHuman Immunology
Volume28
Issue number4
DOIs
Publication statusPublished - Jan 1 1990

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Begovich, A. B., Helmuth, R. C., Oksenberg, J. R., Sakai, K., Tabira, T., Sasazuki, T., Steinman, L., & Erlich, H. A. (1990). HLA-DPβ and susceptibility to multiple sclerosis: An analysis of caucasoid and Japanese patient populations. Human Immunology, 28(4), 365-372. https://doi.org/10.1016/0198-8859(90)90031-J