@article{800843d13e1c4284bf0adafdb0e13769,
title = "HLA-DPβ and susceptibility to multiple sclerosis: An analysis of caucasoid and Japanese patient populations",
abstract = "Nonradioactive sequence-specific oligonucleotide (SSO) probes specific for the HLA-DPβ locus have been used in a simple dot-blot assay to DPβ-type samples amplified by the polymerase chain reaction (pcr) from Caucasoid (n = 24) and Japanese (n = 23) patients with multiple sclerosis (ms) as well as ethnically matched controls. In contrast to previous reports, no DPβ allele was found to be increased in either patient population. However, the results do show a dramatic difference in the allele frequencies between the two control populations, further emphasizing the need for ethnically matched controls in studies of HLA and disease.",
author = "Begovich, {Ann B.} and Helmuth, {Rhea C.} and Oksenberg, {Jorge R.} and Koichiro Sakai and Takeshi Tabira and Takehiko Sasazuki and Lawrence Steinman and Erlich, {Henry A.}",
note = "Funding Information: ACKNOWLEDGMENTS We thank T. Bugawan for developing the DP~3 typing system and invaluable advice, Dr. J. Bell for insightful discussions, Dr. W. Klitz for help with the contingency table test analysis, Drs. T. Sunohara and K. Takahashi for collecting and preparing the Japanese patient samples, and K. Levenson and S. Kurita for preparation of the manuscript. We are also grateful to Dr. Y. Nishimura for providing us with information and references on the genetic homogeneity of the Japanese population. This work was supported in part by a grant from the National Multiple Sclerosis Society to L.S.J.R.O. and K.S. are fellows of the National Multiple Sclerosis Society.",
year = "1990",
month = aug,
doi = "10.1016/0198-8859(90)90031-J",
language = "English",
volume = "28",
pages = "365--372",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "4",
}