TY - JOUR
T1 - HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese
AU - Sato, Shinya
AU - Isobe, Noriko
AU - Yoshimura, Satoshi
AU - Kanamori, Yuji
AU - Masaki, Katsuhisa
AU - Matsushita, Takuya
AU - Kira, Jun-Ichi
N1 - Funding Information:
Dr. Isobe receives a postdoctoral fellowship from the Uehara Memorial Foundation.
Funding Information:
This work was supported, in part, by a Health and Labour Sciences Research Grant on Intractable Diseases ( H22-Nanchi-Ippan-130 ) (Neuroimmunological Diseases, H23-Nanchi-Ippan-017 ) from the Ministry of Health, Labour, and Welfare, Japan , and a grant-in-aid (Scientific Research B; No. 22390178 , Challenging Exploratory Research; No. 23659459 ) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan .
Funding Information:
Dr. Matsushita has received speaker honoraria from Bayer Schering Pharma and Pfizer and receives research support from Bayer Schering Pharma, the Ministry of Health, Labour, and Welfare of Japan, the Japan Science and Technology Agency, the Ministry of Education, Culture, Sports, Science, and Technology, Japan, and the Kaibara Morikazu Medical Science Promotion Foundation, Japan.
Funding Information:
Dr. Kira serves as an editorial board member of Multiple Sclerosis , The Open Neurology Journal , and Journal of the Neurological Sciences . He is a consultant for Biogen Idec Japan, and has received honoraria from Bayer Healthcare and funding for a trip from Bayer Healthcare and Biogen Idec Japan. He is funded by grants from the Japan Science and Technology Agency and the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
PY - 2012/10/15
Y1 - 2012/10/15
N2 - To determine the relationship between susceptibility to atopic myelitis (AM) and polymorphisms of the human leukocyte antigen (HLA)- DPB1 and - DRB1 alleles, we compared each phenotype frequency between 55 AM patients and 367 unrelated healthy controls in Japan. The HLA- DPB1* 0201 allele was significantly more frequent in AM patients than in healthy controls (54.5% vs. 31.9%, corrected P value = 0.0150, odds ratio = 2.564, 95% confidence interval = 1.444-4.554). Our result suggests that the immunogenetic background of AM differs from that of other CNS autoimmune diseases, such as multiple sclerosis and neuromyelitis optica, which show distinct HLA class II associations.
AB - To determine the relationship between susceptibility to atopic myelitis (AM) and polymorphisms of the human leukocyte antigen (HLA)- DPB1 and - DRB1 alleles, we compared each phenotype frequency between 55 AM patients and 367 unrelated healthy controls in Japan. The HLA- DPB1* 0201 allele was significantly more frequent in AM patients than in healthy controls (54.5% vs. 31.9%, corrected P value = 0.0150, odds ratio = 2.564, 95% confidence interval = 1.444-4.554). Our result suggests that the immunogenetic background of AM differs from that of other CNS autoimmune diseases, such as multiple sclerosis and neuromyelitis optica, which show distinct HLA class II associations.
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U2 - 10.1016/j.jneuroim.2012.07.007
DO - 10.1016/j.jneuroim.2012.07.007
M3 - Article
C2 - 22884298
AN - SCOPUS:84865650287
SN - 0165-5728
VL - 251
SP - 110
EP - 113
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -
