HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans

Kenji Hirayama, Sho Matsushita, Ikuo Kikuchi, Masahiko Iuchi, Nobuo Ohta, Takehiko Sasazuki

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Antigens that produce an antibody response in some members of a species may fail to do so in others. The response to an antigen is controlled by a gene termed the immune response (Ir) gene, which is transmitted as a single dominant trait. We have provided evidence for similar immune suppression (Is) genes which control non-responsiveness through the antigen specific suppressor T cell 1-6. The non-responsiveness is also dominantly inherited and the Is genes are linked to the histocompatibility (HLA) antigen system. Here we report that the HLA-DR2 molecule from a non-responder haplotype (HLA-Dw12-DR2-DQwl) is required for the proliferative T cell response to schistosoma japonicum (Sj) antigen, as a restriction element, indicating that the HLA-DR2 is the product of the Ir gene, and that the HLA-DQwl molecule of the non-responder haplotype is important in the antigen-specific suppression of the response to this antigen, suggesting that it is the product of the Is gene. We therefore conclude that the HLA-DR and DQ molecules, which are controlled by the distinct genes in the MHC multigene family, regulate immune response and immune suppression and that the gene for HLA-DQ is epistatic to that for HLA-DR in controlling the immune response to schistosomal antigen in humans.

Original languageEnglish
Pages (from-to)426-430
Number of pages5
JournalNature
Volume327
Issue number6121
DOIs
Publication statusPublished - Jan 1 1987

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HLA-DQ Antigens
HLA-DR Antigens
Antigens
HLA-DR2 Antigen
Genes
Haplotypes
Schistosoma japonicum
T-Lymphocytes
Histocompatibility Antigens
Multigene Family
HLA Antigens
Antibody Formation

All Science Journal Classification (ASJC) codes

  • General

Cite this

Hirayama, K., Matsushita, S., Kikuchi, I., Iuchi, M., Ohta, N., & Sasazuki, T. (1987). HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. Nature, 327(6121), 426-430. https://doi.org/10.1038/327426a0

HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. / Hirayama, Kenji; Matsushita, Sho; Kikuchi, Ikuo; Iuchi, Masahiko; Ohta, Nobuo; Sasazuki, Takehiko.

In: Nature, Vol. 327, No. 6121, 01.01.1987, p. 426-430.

Research output: Contribution to journalArticle

Hirayama, K, Matsushita, S, Kikuchi, I, Iuchi, M, Ohta, N & Sasazuki, T 1987, 'HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans', Nature, vol. 327, no. 6121, pp. 426-430. https://doi.org/10.1038/327426a0
Hirayama K, Matsushita S, Kikuchi I, Iuchi M, Ohta N, Sasazuki T. HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. Nature. 1987 Jan 1;327(6121):426-430. https://doi.org/10.1038/327426a0
Hirayama, Kenji ; Matsushita, Sho ; Kikuchi, Ikuo ; Iuchi, Masahiko ; Ohta, Nobuo ; Sasazuki, Takehiko. / HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. In: Nature. 1987 ; Vol. 327, No. 6121. pp. 426-430.
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