HLA-DQw3 in Japanese summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum

M. Ando, K. Hirayama, K. Soda, R. Okubo, S. Araki, Takehiko Sasazuki

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55 Citations (Scopus)

Abstract

The phenotype of the major histocompatibility complex, loci A, B, C, DR, and DQ, was studied in 66 patients with Japanese summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum, and the results were compared with those obtained from 472 normal healthy subjects. Our results showed an increase in the frequency of HLA-DQw3 antigen in the patients (66% compared with 49% in the normal healthy control subjects: χ 2 = 5.48, p = 0.018, RR = 1.92), suggesting the importance of the host factors for the generation of this disease. The association between HLA-DQw3 as an immune suppression gene and the disease is discussed.

Original languageEnglish
Pages (from-to)948-950
Number of pages3
JournalAmerican Review of Respiratory Disease
Volume140
Issue number4
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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