HLA-linked immune suppression in humans

Takehiko Sasazuki, I. Kikuchi, K. Hirayama, S. Matsushita, N. Ohta, Y. Nishimura

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30 Citations (Scopus)

Abstract

There is no doubt that HLA-DR molecules are acting as the products of HLA-linked immune response genes (Ir-genes), because (i) HLA-DR molecules are the restriction elements in the interaction between CD4+ helper T cells and antigen-presenting cells (APC) to respond to many antigens such as streptococcal cell wall antigen (SCW) (Nishimura and Sasazuki, 1983; Sone et al., 1985; Hizayama et al., 1986), schistosomal antigen (Sj) (Hirayama et al., 1987), Mycobacterium leprae antigen (ML) (Kikuchi et al., 1986) and so on; and (ii) anti-HLA-DR monoclonal antibodies completely abolish the immune response to those antigens (Nishimura and Sasazuki, 1983; Sone et al., 1985). However, genetic analysis of the immune response to those antigens in families or populations revealed that responsiveness is recessive and non-responsiveness to those antigens is a dominant genetic trait that is tightly linked to HLA (Sasazuki et al., 1980a, 1983; Watanabe et al., 1988). This is completely opposite to the situation under the Ir-gene control where responsiveness is dominant and non-responsiveness is recessive. In this paper, we report evidence of how we came across the concept of HLA-linked immune suppression genes (Is-genes) besides Ir-genes, and show evidence for the epistatic interaction between HLA-DR and DQ to determine the immune response to several antigens in humans.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalImmunology
Issue numberSUPPL. 2
Publication statusPublished - Jan 1 1989

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Sasazuki, T., Kikuchi, I., Hirayama, K., Matsushita, S., Ohta, N., & Nishimura, Y. (1989). HLA-linked immune suppression in humans. Immunology, (SUPPL. 2), 21-24.