HLA-Linked susceptibility and resistance to Takayasu Arteritis

Rui Ping Dong, Akinori Kimura, Fujio Numano, Yasuharu Nishimura, Takehiko Sasazuki

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

To investigate genetic factors involved in the pathogenesis of Takayasu arteritis, patients in the Japanese population were examined for HLA-A, -B, and -C alleles by serological typing and for HLA-DR, DQ, and DP alleles by DNA typing using polymerase chain reaction (PCR)/sequence-specific oligonucleotide probe (SSOP) analysis. The frequencies of HLA-Bw52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601, and DPB1*0901 alleles were significantly increased and the frequencies of HLA-Bw54, DRB1*0405, DRB4*0101, DQA1*0301, and DQB1*0401 alleles were significantly decreased. Strong linkage disequilibria among the increased alleles and among the decreased alleles were evident in the Japanese population. Therefore, the haplotype of HLA-Bw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601-DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another haplotype of HLA-Bw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1*0401 may confer resistance to the disease. These observations clearly indicate that HLA-linked gene(s) are involved in the development of Takayasu arteritis.

Original languageEnglish
Pages (from-to)73-80
Number of pages8
JournalHeart and Vessels
Volume7
Issue number1 Supplement
DOIs
Publication statusPublished - Mar 1 1992

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Takayasu Arteritis
Alleles
HLA-DRB1 Chains
Haplotypes
HLA-DP Antigens
HLA-DQ Antigens
Disease Resistance
HLA-A Antigens
HLA-B Antigens
DNA Fingerprinting
Oligonucleotide Probes
Linkage Disequilibrium
HLA-DR Antigens
Population
Polymerase Chain Reaction
Genes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Dong, R. P., Kimura, A., Numano, F., Nishimura, Y., & Sasazuki, T. (1992). HLA-Linked susceptibility and resistance to Takayasu Arteritis. Heart and Vessels, 7(1 Supplement), 73-80. https://doi.org/10.1007/BF01744548

HLA-Linked susceptibility and resistance to Takayasu Arteritis. / Dong, Rui Ping; Kimura, Akinori; Numano, Fujio; Nishimura, Yasuharu; Sasazuki, Takehiko.

In: Heart and Vessels, Vol. 7, No. 1 Supplement, 01.03.1992, p. 73-80.

Research output: Contribution to journalArticle

Dong, RP, Kimura, A, Numano, F, Nishimura, Y & Sasazuki, T 1992, 'HLA-Linked susceptibility and resistance to Takayasu Arteritis', Heart and Vessels, vol. 7, no. 1 Supplement, pp. 73-80. https://doi.org/10.1007/BF01744548
Dong RP, Kimura A, Numano F, Nishimura Y, Sasazuki T. HLA-Linked susceptibility and resistance to Takayasu Arteritis. Heart and Vessels. 1992 Mar 1;7(1 Supplement):73-80. https://doi.org/10.1007/BF01744548
Dong, Rui Ping ; Kimura, Akinori ; Numano, Fujio ; Nishimura, Yasuharu ; Sasazuki, Takehiko. / HLA-Linked susceptibility and resistance to Takayasu Arteritis. In: Heart and Vessels. 1992 ; Vol. 7, No. 1 Supplement. pp. 73-80.
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