HLA—Bw52 in Takayasu Disease

I. Isohisa, F. Numano, H. Maezawa, Takehiko Sasazuki

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Takayasu disease is characterized by a pulseless condition which most often occurs in young females from Asian or South American areas. The cause of this disease remains obscure. Recently we encountered monozygotic, Japanese identical twin sisters, both of whom were diagnosed as having Takayasu disease. A genetically related factor was considered and HLA analysis was carried out. A population study on HLA typing analyses of 65 patients with Takayasu disease revealed a high frequency of HLA—B5 as compared with 128 healthy Japanese (x2: 17.0, P < 10–4). Subgroups of B5, Bw51 and Bw52 were successively studied in 82 patients with this disease. Bw51 antigen was found in 12.2% of patients with Takayasu disease and in 19.5% of 128 healthy Japanese. Contrarily, Bw52 antigen was confirmed in 43.9% of patients, a statistically significant frequency with the level of 26.5 in the x2 test (cP < 3 < 10–4) when compared with 12.5% in normal Japanese. Thus a genetically related factor in the pathogenesis of Takayasu disease has to be considered.

Original languageEnglish
Pages (from-to)246-248
Number of pages3
JournalTissue antigens
Volume12
Issue number4
DOIs
Publication statusPublished - Jan 1 1978
Externally publishedYes

Fingerprint

Takayasu Arteritis
Antigens
Histocompatibility Testing
Monozygotic Twins
Siblings
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Isohisa, I., Numano, F., Maezawa, H., & Sasazuki, T. (1978). HLA—Bw52 in Takayasu Disease. Tissue antigens, 12(4), 246-248. https://doi.org/10.1111/j.1399-0039.1978.tb01332.x

HLA—Bw52 in Takayasu Disease. / Isohisa, I.; Numano, F.; Maezawa, H.; Sasazuki, Takehiko.

In: Tissue antigens, Vol. 12, No. 4, 01.01.1978, p. 246-248.

Research output: Contribution to journalArticle

Isohisa, I, Numano, F, Maezawa, H & Sasazuki, T 1978, 'HLA—Bw52 in Takayasu Disease', Tissue antigens, vol. 12, no. 4, pp. 246-248. https://doi.org/10.1111/j.1399-0039.1978.tb01332.x
Isohisa I, Numano F, Maezawa H, Sasazuki T. HLA—Bw52 in Takayasu Disease. Tissue antigens. 1978 Jan 1;12(4):246-248. https://doi.org/10.1111/j.1399-0039.1978.tb01332.x
Isohisa, I. ; Numano, F. ; Maezawa, H. ; Sasazuki, Takehiko. / HLA—Bw52 in Takayasu Disease. In: Tissue antigens. 1978 ; Vol. 12, No. 4. pp. 246-248.
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