Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system

Akira Matsumoto, Hirohito Kuwata, Shinichiro Kimura, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-oka, Akiko Watanabe, Hironori Yamada, Hitoshi Ishii, Taiki Miyazawa, Siyuan Chen, Toshiaki Baba, Hiroshi Yoshida, Taichi Nakamura, Hiroshi Inoue, Yoshihiro Ogawa, Miyako Tanaka, Yuji Miyahara, Takayoshi Suganami

Research output: Contribution to journalArticle

Abstract

Accumulating evidence demonstrates that not only sustained elevation of blood glucose levels but also the glucose fluctuation represents key determinants for diabetic complications and mortality. Current closed-loop insulin therapy option is limited to the use of electronics-based systems, although it poses some technical issues with high cost. Here we demonstrate an electronics-free, synthetic boronate gel-based insulin-diffusion-control device technology that can cope with glucose fluctuations and potentially address the electronics-derived issues. The gel was combined with hemodialysis hollow fibers and scaled suitable for rats, serving as a subcutaneously implantable, insulin-diffusion-active site in a manner dependent on the subcutaneous glucose. Continuous glucose monitoring tests revealed that our device not only normalizes average glucose level of rats, but also markedly ameliorates the fluctuations over timescale of a day without inducing hypoglycemia. With inherent stability, diffusion-dependent scalability, and week-long & acute glucose-responsiveness, our technology may offer a low-cost alternative to current electronics-based approaches.

Original languageEnglish
Article number313
JournalCommunications Biology
Volume3
Issue number1
DOIs
Publication statusPublished - Dec 1 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

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  • Cite this

    Matsumoto, A., Kuwata, H., Kimura, S., Matsumoto, H., Ochi, K., Moro-oka, Y., Watanabe, A., Yamada, H., Ishii, H., Miyazawa, T., Chen, S., Baba, T., Yoshida, H., Nakamura, T., Inoue, H., Ogawa, Y., Tanaka, M., Miyahara, Y., & Suganami, T. (2020). Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system. Communications Biology, 3(1), [313]. https://doi.org/10.1038/s42003-020-1026-x