Homogeneous bioassays based on the manipulation of magnetic nanoparticles by rotating and alternating magnetic FieldsA comparison

Jan Henrik Dieckhoff, Takashi Yoshida, Keiji Enpuku, Meinhard Schilling, Frank Ludwig

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The rotating magnetic field as a source of magnetic nanoparticle manipulation for the use in homogenous bioassays is presented and compared with the frequently used alternating magnetic field technique. For the investigation of the impact of the rotating and alternating field mode on the biomolecule detection, a fluxgate based measurement system has been used. This system detects the MNPs magnetization stray field and calculates the phase lag between the aligning field and the MNPs magnetization. By analyzing the phase lag, the analysis is not altered by changes in MNP concentration. The measured phase lag spectra show a significant difference between both magnetic field modes and agree well with simulations based on the Fokker-Planck equation. A modeling of binding experiments based on these simulations predicts a higher sensitivity for the rotating magnetic field manipulation.

Original languageEnglish
Article number6332681
Pages (from-to)3792-3795
Number of pages4
JournalIEEE Transactions on Magnetics
Volume48
Issue number11
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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