Homogeneous Oligomeric Ligands Prepared via Radical Polymerization that Recognize and Neutralize a Target Peptide

Yu Hoshino, Shohei Taniguchi, Hinata Takimoto, Sotaro Akashi, Sho Katakami, Yusuke Yonamine, Yoshiko Miura

Research output: Contribution to journalArticle

Abstract

Abiotic ligands that bind to specific biomolecules have attracted attention as substitutes for biomolecular ligands, such as antibodies and aptamers. Radical polymerization enables the production of robust polymeric ligands from inexpensive functional monomers. However, little has been reported about the production of monodispersed polymeric ligands. Herein, we present homogeneous ligands prepared via radical polymerization that recognize epitope sequences on a target peptide and neutralize the toxicity of the peptide. Taking advantage of controlled radical polymerization and separation, a library of multifunctional oligomers with discrete numbers of functional groups was prepared. Affinity screening revealed that the sequence specificity of the oligomer ligands strongly depended on the number of functional groups. The process reported here will become a general step for the development of abiotic ligands that recognize specific peptide sequences.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalAngewandte Chemie - International Edition
Volume59
Issue number2
DOIs
Publication statusPublished - Jan 7 2020

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Free radical polymerization
Peptides
Ligands
Oligomers
Functional groups
Epitopes
Biomolecules
Antibodies
Toxicity
Screening
Monomers

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Homogeneous Oligomeric Ligands Prepared via Radical Polymerization that Recognize and Neutralize a Target Peptide. / Hoshino, Yu; Taniguchi, Shohei; Takimoto, Hinata; Akashi, Sotaro; Katakami, Sho; Yonamine, Yusuke; Miura, Yoshiko.

In: Angewandte Chemie - International Edition, Vol. 59, No. 2, 07.01.2020, p. 679-683.

Research output: Contribution to journalArticle

Hoshino, Yu ; Taniguchi, Shohei ; Takimoto, Hinata ; Akashi, Sotaro ; Katakami, Sho ; Yonamine, Yusuke ; Miura, Yoshiko. / Homogeneous Oligomeric Ligands Prepared via Radical Polymerization that Recognize and Neutralize a Target Peptide. In: Angewandte Chemie - International Edition. 2020 ; Vol. 59, No. 2. pp. 679-683.
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