Hormone replacement Up-to-date. Adrenopause and DHEA replacement therapy

Ohnaka Keizo, Ryoichi Takayanagi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


It is well known that serum levels of DHEA and its sulfate form DHEA-S decline along with aging. This phenomenon is called adrenopause in contrast to menopause. Experimental studies show that DHEA has many beneficial effects such as anti-diabetic, anti-atherosclerosis, and anti-osteoporosis effects. Therefore, DHEA replacement has been performed as anti-aging therapy. Several clinical trials of DHEA replacement demonstrated the improvement of sense of well-being, lipid metabolism, and bone metabolism. We recently reported on the result of short-term administration of DHEA in healthy Japanese volunteer men. It is thought that further accumulation of original data is necessary to promote DHEA replacement therapy in Japan.

Original languageEnglish
Pages (from-to)1334-1340
Number of pages7
JournalClinical calcium
Issue number9
Publication statusPublished - Jan 1 2007

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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