Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses

Takashi Hasegawa, Masao Okuda, Masahiko Makino, Kenji Hiromatsu, Kikuo Nomoto, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    38 Citations (Scopus)

    Abstract

    The bacterial elimination after infection with Listeria monocytogenes was impaired in mice with murine acquired immunodeficiency syndrome (MAIDS) by infection with LP-BM5 murine leukemia virus. Oral administration of hot water extracts of Chlorella vulgaris (CVE) restored the capacity of MAIDS mice to eliminate L. monocytogenes in association with improvement of the deteriorated immune response to L. monocytogenes. DTH response to Listeria in CVE-treated MAIDS mice was significantly higher than that of MAIDS mice after Listeria infection in association with increases in number of CD4+CD8- and CD4-CD8+ αβ T-cells in the infected sites. CVE might be effective in the treatment of opportunistic infection in retrovirus-induced immunodeficient patients.

    Original languageEnglish
    Pages (from-to)505-512
    Number of pages8
    JournalInternational Journal of Immunopharmacology
    Volume17
    Issue number6
    DOIs
    Publication statusPublished - Jan 1 1995

    Fingerprint

    Murine Acquired Immunodeficiency Syndrome
    Chlorella vulgaris
    Murine Leukemia Viruses
    Opportunistic Infections
    Listeria monocytogenes
    Inbred C57BL Mouse
    Water
    Listeriosis
    Listeria
    Retroviridae
    Infection
    Oral Administration
    T-Lymphocytes

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Pharmacology

    Cite this

    Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses. / Hasegawa, Takashi; Okuda, Masao; Makino, Masahiko; Hiromatsu, Kenji; Nomoto, Kikuo; Yoshikai, Yasunobu.

    In: International Journal of Immunopharmacology, Vol. 17, No. 6, 01.01.1995, p. 505-512.

    Research output: Contribution to journalArticle

    Hasegawa, Takashi ; Okuda, Masao ; Makino, Masahiko ; Hiromatsu, Kenji ; Nomoto, Kikuo ; Yoshikai, Yasunobu. / Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine leukemia viruses. In: International Journal of Immunopharmacology. 1995 ; Vol. 17, No. 6. pp. 505-512.
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    abstract = "The bacterial elimination after infection with Listeria monocytogenes was impaired in mice with murine acquired immunodeficiency syndrome (MAIDS) by infection with LP-BM5 murine leukemia virus. Oral administration of hot water extracts of Chlorella vulgaris (CVE) restored the capacity of MAIDS mice to eliminate L. monocytogenes in association with improvement of the deteriorated immune response to L. monocytogenes. DTH response to Listeria in CVE-treated MAIDS mice was significantly higher than that of MAIDS mice after Listeria infection in association with increases in number of CD4+CD8- and CD4-CD8+ αβ T-cells in the infected sites. CVE might be effective in the treatment of opportunistic infection in retrovirus-induced immunodeficient patients.",
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    AU - Makino, Masahiko

    AU - Hiromatsu, Kenji

    AU - Nomoto, Kikuo

    AU - Yoshikai, Yasunobu

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