HPLC analysis of naturally occurring free d-amino acids in mammals

Yurika Miyoshi, Reiko Koga, Tsubasa Oyama, Hai Han, Kyoko Ueno, Kei Masuyama, Yusuke Itoh, Kenji Hamase

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

d-Amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino acid research in real biological matrices. In this review, we would like to describe the d-amino acid research, from the discovery of appreciable amounts of free d-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of d-amino acids in mammals including human beings will be discussed.

Original languageEnglish
Pages (from-to)42-49
Number of pages8
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume69
DOIs
Publication statusPublished - Oct 1 2012

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Mammals
High Pressure Liquid Chromatography
Amino Acids
Metabolomics
Enantiomers
Biomarkers
Research
Technology
Liquids

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry

Cite this

HPLC analysis of naturally occurring free d-amino acids in mammals. / Miyoshi, Yurika; Koga, Reiko; Oyama, Tsubasa; Han, Hai; Ueno, Kyoko; Masuyama, Kei; Itoh, Yusuke; Hamase, Kenji.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 69, 01.10.2012, p. 42-49.

Research output: Contribution to journalReview article

Miyoshi, Yurika ; Koga, Reiko ; Oyama, Tsubasa ; Han, Hai ; Ueno, Kyoko ; Masuyama, Kei ; Itoh, Yusuke ; Hamase, Kenji. / HPLC analysis of naturally occurring free d-amino acids in mammals. In: Journal of Pharmaceutical and Biomedical Analysis. 2012 ; Vol. 69. pp. 42-49.
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