Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

Douglas G. Millar, Kristine M. Garza, Bernhard Odermatt, Alisha R. Elford, Nobuyuki Ono, Zihai Li, Pamela S. Ohashi

Research output: Contribution to journalArticlepeer-review

228 Citations (Scopus)

Abstract

Pathogens or pathogen-associated molecular patterns can signal to cells of the innate immune system and trigger effective adaptive immunity. However, relatively little is known about how the innate immune system detects tissue injury or necrosis. Evidence suggests that the release of heat-shock proteins (HSPs) may provide adjuvant-like signals, but the ability of HSPs to promote activation or tolerance in vivo has not been addressed. In this study we show that Hsp70 promotes dendritic cell (DC) function and, together with antigen, triggers autoimmune disease in vivo.

Original languageEnglish
Pages (from-to)1469-1476
Number of pages8
JournalNature medicine
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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