Human beta defensin-3 engineered keratinocyte sheets constructed by a magnetic force-based tissue engineering technique

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Abstract

A multilayered keratinocyte sheet overexpressing human beta defensin-3 (HBD-3) gene was prepared by the magnetic force-based tissue engineering technique. The cell sheet demonstrated significant antimicrobial activity, indicating that the therapeutic introduction of HBD-3 gene into cell sheets may provide a new gene therapy strategy for infectious diseases.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalJournal of Bioscience and Bioengineering
Volume108
Issue number3
DOIs
Publication statusPublished - Sep 1 2009

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Tissue Engineering
Keratinocytes
Tissue engineering
Genes
Gene therapy
Genetic Therapy
Communicable Diseases
human beta-defensin 3
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

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abstract = "A multilayered keratinocyte sheet overexpressing human beta defensin-3 (HBD-3) gene was prepared by the magnetic force-based tissue engineering technique. The cell sheet demonstrated significant antimicrobial activity, indicating that the therapeutic introduction of HBD-3 gene into cell sheets may provide a new gene therapy strategy for infectious diseases.",
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