Human colorectal CD24+ cancer stem cells are susceptible to epithelial-mesenchymal transition

Miho Okano, Masamitsu Konno, Yoshihiro Kano, Hirotoshi Kim, Koichi Kawamoto, Masahisa Ohkuma, Naotsugu Haraguchi, Takehiko Yokobori, Koshi Mimori, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

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6 Citations (Scopus)

Abstract

Conventional cancer chemotherapy preferentially destroys non-stem cancer cells within a tumor, and a subpopulation of cancer stem cells (CSCs) is more resistant and survives, leading to relapses and metastasis. Howeve, recent studies suggest that CD24 and susceptibility to epithelial-mesenchymal transition (EMT) can serve as markers of CSCs. We report that CD24+ cells are susceptible to induction of EMT, a phenotype important for cancer metastasis. We studied the responsiveness of CSC markers to TGF-β, an effective EMT inducer. The data on CD24 demonstrated that CD24+ cells are susceptible to EMT, a phenotype important for cancer metastasis in two colorectal cancer cell lines, the CaR-1 and CCK81. CD24+ cells expressed Notch 1 in response to exposure to TGF-β in culture and showed higher tumorigenic activity compared to controls. This evidence shows that CD24+ cells are susceptible to EMT induction and to cancer progression and is indicative of the candidacy of CD24 as a therapeutic target in CSC.

Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalInternational journal of oncology
Volume45
Issue number2
DOIs
Publication statusPublished - Aug 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Okano, M., Konno, M., Kano, Y., Kim, H., Kawamoto, K., Ohkuma, M., Haraguchi, N., Yokobori, T., Mimori, K., Yamamoto, H., Sekimoto, M., Doki, Y., Mori, M., & Ishii, H. (2014). Human colorectal CD24+ cancer stem cells are susceptible to epithelial-mesenchymal transition. International journal of oncology, 45(2), 575-580. https://doi.org/10.3892/ijo.2014.2462