Human herpesvirus 6 (HHV-6)-associated pleurisy after unrelated cord blood transplantation in children with chemotherapy-resistant malignant lymphoma

Aiko Suminoe, Akinobu Matsuzaki, Yuhki Koga, Koichi Kusuhara, Toshiro Hara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Two children, 5 and 10 years of age, received unrelated cord blood transplantation (CBT) for malignant lymphoma. Both of them suffered from pleurisy with and without interstitial pneumonitis after transplantation. By the quantitative real-time polymerase chain reaction, human herpesvirus 6 (HHV-6) variant B DNA was detected in pleural effusion. This is the first report of HHV-6-associated pleurisy after hematopoietic stem cell transplantation. HHV-6-associated pleurisy should be considered as a complication after hematopoietic stem cell transplantation even in the absence of pneumonitis. Quantitative polymerase chain reaction is a useful tool for rapid detection of viral DNA, which may facilitate precise diagnosis and appropriate treatment.

Original languageEnglish
Pages (from-to)709-712
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume29
Issue number10
DOIs
Publication statusPublished - Oct 1 2007

Fingerprint

Human Herpesvirus 6
Pleurisy
Fetal Blood
Lymphoma
Transplantation
Hematopoietic Stem Cell Transplantation
Drug Therapy
Interstitial Lung Diseases
Viral DNA
Pleural Effusion
Real-Time Polymerase Chain Reaction
Pneumonia
Polymerase Chain Reaction
DNA
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Human herpesvirus 6 (HHV-6)-associated pleurisy after unrelated cord blood transplantation in children with chemotherapy-resistant malignant lymphoma. / Suminoe, Aiko; Matsuzaki, Akinobu; Koga, Yuhki; Kusuhara, Koichi; Hara, Toshiro.

In: Journal of Pediatric Hematology/Oncology, Vol. 29, No. 10, 01.10.2007, p. 709-712.

Research output: Contribution to journalArticle

@article{f4538ed0987846b59234eccde71437fd,
title = "Human herpesvirus 6 (HHV-6)-associated pleurisy after unrelated cord blood transplantation in children with chemotherapy-resistant malignant lymphoma",
abstract = "Two children, 5 and 10 years of age, received unrelated cord blood transplantation (CBT) for malignant lymphoma. Both of them suffered from pleurisy with and without interstitial pneumonitis after transplantation. By the quantitative real-time polymerase chain reaction, human herpesvirus 6 (HHV-6) variant B DNA was detected in pleural effusion. This is the first report of HHV-6-associated pleurisy after hematopoietic stem cell transplantation. HHV-6-associated pleurisy should be considered as a complication after hematopoietic stem cell transplantation even in the absence of pneumonitis. Quantitative polymerase chain reaction is a useful tool for rapid detection of viral DNA, which may facilitate precise diagnosis and appropriate treatment.",
author = "Aiko Suminoe and Akinobu Matsuzaki and Yuhki Koga and Koichi Kusuhara and Toshiro Hara",
year = "2007",
month = "10",
day = "1",
doi = "10.1097/MPH.0b013e318142b50d",
language = "English",
volume = "29",
pages = "709--712",
journal = "Journal of Pediatric Hematology/Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Human herpesvirus 6 (HHV-6)-associated pleurisy after unrelated cord blood transplantation in children with chemotherapy-resistant malignant lymphoma

AU - Suminoe, Aiko

AU - Matsuzaki, Akinobu

AU - Koga, Yuhki

AU - Kusuhara, Koichi

AU - Hara, Toshiro

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Two children, 5 and 10 years of age, received unrelated cord blood transplantation (CBT) for malignant lymphoma. Both of them suffered from pleurisy with and without interstitial pneumonitis after transplantation. By the quantitative real-time polymerase chain reaction, human herpesvirus 6 (HHV-6) variant B DNA was detected in pleural effusion. This is the first report of HHV-6-associated pleurisy after hematopoietic stem cell transplantation. HHV-6-associated pleurisy should be considered as a complication after hematopoietic stem cell transplantation even in the absence of pneumonitis. Quantitative polymerase chain reaction is a useful tool for rapid detection of viral DNA, which may facilitate precise diagnosis and appropriate treatment.

AB - Two children, 5 and 10 years of age, received unrelated cord blood transplantation (CBT) for malignant lymphoma. Both of them suffered from pleurisy with and without interstitial pneumonitis after transplantation. By the quantitative real-time polymerase chain reaction, human herpesvirus 6 (HHV-6) variant B DNA was detected in pleural effusion. This is the first report of HHV-6-associated pleurisy after hematopoietic stem cell transplantation. HHV-6-associated pleurisy should be considered as a complication after hematopoietic stem cell transplantation even in the absence of pneumonitis. Quantitative polymerase chain reaction is a useful tool for rapid detection of viral DNA, which may facilitate precise diagnosis and appropriate treatment.

UR - http://www.scopus.com/inward/record.url?scp=35148824642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35148824642&partnerID=8YFLogxK

U2 - 10.1097/MPH.0b013e318142b50d

DO - 10.1097/MPH.0b013e318142b50d

M3 - Article

C2 - 17921853

AN - SCOPUS:35148824642

VL - 29

SP - 709

EP - 712

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

IS - 10

ER -