Abstract
Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.
| Original language | English |
|---|---|
| Pages (from-to) | 229-234 |
| Number of pages | 6 |
| Journal | Tissue Antigens |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 30 1999 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Biochemistry
- Genetics
Cite this
Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation. / Juji, T.; Watanabe, Y.; Ishikawa, Yoshihide; Fujiwara, K.; Tonami, H.; Tanaka, H.; Satake, M.; Akaza, T.; Tadokoro, K.; Kodera, Y.; Sasazuki, Takehiko; Morishima, Y.; Takaku, F.
In: Tissue Antigens, Vol. 54, No. 3, 30.09.1999, p. 229-234.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation
AU - Juji, T.
AU - Watanabe, Y.
AU - Ishikawa, Yoshihide
AU - Fujiwara, K.
AU - Tonami, H.
AU - Tanaka, H.
AU - Satake, M.
AU - Akaza, T.
AU - Tadokoro, K.
AU - Kodera, Y.
AU - Sasazuki, Takehiko
AU - Morishima, Y.
AU - Takaku, F.
PY - 1999/9/30
Y1 - 1999/9/30
N2 - Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.
AB - Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.
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UR - http://www.scopus.com/inward/citedby.url?scp=0032824434&partnerID=8YFLogxK
U2 - 10.1034/j.1399-0039.1999.540303.x
DO - 10.1034/j.1399-0039.1999.540303.x
M3 - Article
VL - 54
SP - 229
EP - 234
JO - HLA
JF - HLA
SN - 2059-2302
IS - 3
ER -