Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation

T. Juji, Y. Watanabe, Yoshihide Ishikawa, K. Fujiwara, H. Tonami, H. Tanaka, M. Satake, T. Akaza, K. Tadokoro, Y. Kodera, Takehiko Sasazuki, Y. Morishima, F. Takaku

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalTissue Antigens
Volume54
Issue number3
DOIs
Publication statusPublished - Sep 30 1999

Fingerprint

Human Platelet Antigens
Bone Marrow Transplantation
Disease-Free Survival
Bone
Graft vs Host Disease
Grafts
Haplotypes
Transplants
HLA-A Antigens
HLA-B Antigens
Survival Rate
Transplantation
Alleles
Tissue Donors
Antigens
Survival
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation. / Juji, T.; Watanabe, Y.; Ishikawa, Yoshihide; Fujiwara, K.; Tonami, H.; Tanaka, H.; Satake, M.; Akaza, T.; Tadokoro, K.; Kodera, Y.; Sasazuki, Takehiko; Morishima, Y.; Takaku, F.

In: Tissue Antigens, Vol. 54, No. 3, 30.09.1999, p. 229-234.

Research output: Contribution to journalArticle

Juji, T, Watanabe, Y, Ishikawa, Y, Fujiwara, K, Tonami, H, Tanaka, H, Satake, M, Akaza, T, Tadokoro, K, Kodera, Y, Sasazuki, T, Morishima, Y & Takaku, F 1999, 'Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation', Tissue Antigens, vol. 54, no. 3, pp. 229-234. https://doi.org/10.1034/j.1399-0039.1999.540303.x
Juji, T. ; Watanabe, Y. ; Ishikawa, Yoshihide ; Fujiwara, K. ; Tonami, H. ; Tanaka, H. ; Satake, M. ; Akaza, T. ; Tadokoro, K. ; Kodera, Y. ; Sasazuki, Takehiko ; Morishima, Y. ; Takaku, F. / Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation. In: Tissue Antigens. 1999 ; Vol. 54, No. 3. pp. 229-234.
@article{dcd769531383465fac70c03ec0dfc7b9,
title = "Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation",
abstract = "Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.",
author = "T. Juji and Y. Watanabe and Yoshihide Ishikawa and K. Fujiwara and H. Tonami and H. Tanaka and M. Satake and T. Akaza and K. Tadokoro and Y. Kodera and Takehiko Sasazuki and Y. Morishima and F. Takaku",
year = "1999",
month = "9",
day = "30",
doi = "10.1034/j.1399-0039.1999.540303.x",
language = "English",
volume = "54",
pages = "229--234",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation

AU - Juji, T.

AU - Watanabe, Y.

AU - Ishikawa, Yoshihide

AU - Fujiwara, K.

AU - Tonami, H.

AU - Tanaka, H.

AU - Satake, M.

AU - Akaza, T.

AU - Tadokoro, K.

AU - Kodera, Y.

AU - Sasazuki, Takehiko

AU - Morishima, Y.

AU - Takaku, F.

PY - 1999/9/30

Y1 - 1999/9/30

N2 - Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.

AB - Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.

UR - http://www.scopus.com/inward/record.url?scp=0032824434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032824434&partnerID=8YFLogxK

U2 - 10.1034/j.1399-0039.1999.540303.x

DO - 10.1034/j.1399-0039.1999.540303.x

M3 - Article

VL - 54

SP - 229

EP - 234

JO - HLA

JF - HLA

SN - 2059-2302

IS - 3

ER -