Human T lymphotropic virus type 1 infection influences hepatitis C virus clearance

Y. Kishihara, Norihiro Furusyo, K. Kashiwagi, A. Mitsutake, S. Kashiwagi, J. Hayashi

Research output: Contribution to journalArticle

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Abstract

To explore the effect of human T lymphotropic virus type 1 (HTLV-1) infection on hepatitis C virus (HCV) infection, a survey for these viral infections was conducted that involved 2280 residents in an area in which HTLV-1 and HCV are endemic. The response of patients with HCV and HTLV-1 to interferon (IFN)-α treatment was also assessed. Antibody to HCV was detected in 13.8% of the residents tested, and antibody to HTLV-1 was detected in 15.4%. The prevalence of HCV RNA was significantly higher among residents who had antibodies to both HCV and HTLV-1 than in those who had antibodies to HCV only (P < .05). Sustained elimination of HCV RNA by IFN was significantly more frequent among patients with HCV alone than among those with HCV and HTLV-1. By logistic regression analysis, HTLV-1 infection was associated with nonresponse to IFN treatment. Thus, HTLV-1 infection affects the clearance, both natural and in association with IFN treatment, of HCV.

Original languageEnglish
Pages (from-to)1114-1119
Number of pages6
JournalJournal of Infectious Diseases
Volume184
Issue number9
DOIs
Publication statusPublished - Nov 1 2001

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Human T-lymphotropic virus 1
Virus Diseases
Hepacivirus
Interferons
Hepatitis C Antibodies
RNA
Interferon Type I
Antibodies
Therapeutics
Logistic Models
Regression Analysis
Viruses

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Kishihara, Y., Furusyo, N., Kashiwagi, K., Mitsutake, A., Kashiwagi, S., & Hayashi, J. (2001). Human T lymphotropic virus type 1 infection influences hepatitis C virus clearance. Journal of Infectious Diseases, 184(9), 1114-1119. https://doi.org/10.1086/323890

Human T lymphotropic virus type 1 infection influences hepatitis C virus clearance. / Kishihara, Y.; Furusyo, Norihiro; Kashiwagi, K.; Mitsutake, A.; Kashiwagi, S.; Hayashi, J.

In: Journal of Infectious Diseases, Vol. 184, No. 9, 01.11.2001, p. 1114-1119.

Research output: Contribution to journalArticle

Kishihara, Y, Furusyo, N, Kashiwagi, K, Mitsutake, A, Kashiwagi, S & Hayashi, J 2001, 'Human T lymphotropic virus type 1 infection influences hepatitis C virus clearance', Journal of Infectious Diseases, vol. 184, no. 9, pp. 1114-1119. https://doi.org/10.1086/323890
Kishihara Y, Furusyo N, Kashiwagi K, Mitsutake A, Kashiwagi S, Hayashi J. Human T lymphotropic virus type 1 infection influences hepatitis C virus clearance. Journal of Infectious Diseases. 2001 Nov 1;184(9):1114-1119. https://doi.org/10.1086/323890
Kishihara, Y. ; Furusyo, Norihiro ; Kashiwagi, K. ; Mitsutake, A. ; Kashiwagi, S. ; Hayashi, J. / Human T lymphotropic virus type 1 infection influences hepatitis C virus clearance. In: Journal of Infectious Diseases. 2001 ; Vol. 184, No. 9. pp. 1114-1119.
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