Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

Katja Jankova, Irakli Javakhishvili, Shingo Kobayashi, Ryohei Koguchi, Daiki Murakami, Toshiki Sonoda, Masaru Tanaka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA), was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1H]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol % of the functional monomer in the copolymer. These functional monomers as physical cross-links are distributed in the PMEA matrix with a Tg of -35 °C, making H-PMEA a solid rubber-like material with recoverable tensile strain. Additionally, mechanical tests revealed its tensile strength, and thermogravimetric analyses confirmed its higher thermostability. The dry and hydration states of H-PMEA were assessed by differential scanning calorimetry, contact angle, and atomic force microscopy measurements. Comparison with viscous PMEA was made. For the first time, we included PVC alongside PET, the surface we usually use as a negative control, in the platelet adhesion test with human blood, and found out that 1.5 times more platelets adhered onto the PVC surface than onto the PET surface, while H-PMEA proved to have a clear edge. Thus, H-PMEA may serve as a suitable replacement for polymers in products contacting blood as it shows potential for making free-standing films, thick coatings, implants, and articles with various geometries for the medicinal industry.

Original languageEnglish
Pages (from-to)4154-4161
Number of pages8
JournalACS Applied Bio Materials
Volume2
Issue number10
DOIs
Publication statusPublished - Oct 21 2019

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Hydration
Hydrogen
Blood
Polymers
Monomers
Platelets
Polyvinyl Chloride
Polyvinyl chlorides
Bearings (structural)
Blood Platelets
Coatings
Tensile Strength
Tensile strain
Atomic Force Microscopy
Rubber
Differential Scanning Calorimetry
Hydrogen Bonding
Free radicals
Thick films
Copolymerization

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

Cite this

Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate). / Jankova, Katja; Javakhishvili, Irakli; Kobayashi, Shingo; Koguchi, Ryohei; Murakami, Daiki; Sonoda, Toshiki; Tanaka, Masaru.

In: ACS Applied Bio Materials, Vol. 2, No. 10, 21.10.2019, p. 4154-4161.

Research output: Contribution to journalArticle

Jankova, Katja ; Javakhishvili, Irakli ; Kobayashi, Shingo ; Koguchi, Ryohei ; Murakami, Daiki ; Sonoda, Toshiki ; Tanaka, Masaru. / Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate). In: ACS Applied Bio Materials. 2019 ; Vol. 2, No. 10. pp. 4154-4161.
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