Hydrogen-bonded frameworks of propylenediamine-N,N′-diacetic acid Pt(II) complexes, synthesis, structural characterization, and antitumor activity

Hoda A. El-Ghamry, Shigeyuki Masaoka, Ken Sakai

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Two Pt(II) complexes of propylenediamine-N,N′-diacetic acid (H 2pdda) have been synthesized in which H2pdda is bidentate and tetradentate. The two complexes, [Pt(C7H14N 2O4)Cl2] (1) and [Pt(C7H 12N2O4)] (2), have been characterized by elemental analysis, IR, mass spectroscopy, and thermal (TGA and DTG) analysis. The crystal structure of 1 and [Pt(C7H12N 2O4)]·3H2O (2a) are reported. In vitro cytotoxic properties of 1 and 2 were evaluated against HEPG2 (liver carcinoma cell lines) and HCT116 (colon carcinoma cell lines), and were compared with the standard anticancer drugs cisplatin (cis-DDP) and doxorubicin (Dox). The obtained data indicate that the two complexes show weak cytotoxic activity against the two tested cell lines, except for 1 which revealed a relatively high activity against HEPG2. Structure-activity relationships have been interpreted.

Original languageEnglish
Pages (from-to)943-955
Number of pages13
JournalJournal of Coordination Chemistry
Volume67
Issue number6
DOIs
Publication statusPublished - Mar 19 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Materials Chemistry

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