Hydrogen-bonded frameworks of propylenediamine-N,N′-diacetic acid Pt(II) complexes, synthesis, structural characterization, and antitumor activity

Hoda A. El-Ghamry, Shigeyuki Masaoka, Ken Sakai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Two Pt(II) complexes of propylenediamine-N,N′-diacetic acid (H 2pdda) have been synthesized in which H2pdda is bidentate and tetradentate. The two complexes, [Pt(C7H14N 2O4)Cl2] (1) and [Pt(C7H 12N2O4)] (2), have been characterized by elemental analysis, IR, mass spectroscopy, and thermal (TGA and DTG) analysis. The crystal structure of 1 and [Pt(C7H12N 2O4)]·3H2O (2a) are reported. In vitro cytotoxic properties of 1 and 2 were evaluated against HEPG2 (liver carcinoma cell lines) and HCT116 (colon carcinoma cell lines), and were compared with the standard anticancer drugs cisplatin (cis-DDP) and doxorubicin (Dox). The obtained data indicate that the two complexes show weak cytotoxic activity against the two tested cell lines, except for 1 which revealed a relatively high activity against HEPG2. Structure-activity relationships have been interpreted.

Original languageEnglish
Pages (from-to)943-955
Number of pages13
JournalJournal of Coordination Chemistry
Volume67
Issue number6
DOIs
Publication statusPublished - Mar 19 2014
Externally publishedYes

Fingerprint

cultured cells
Hydrogen
Cells
acids
Acids
hydrogen
synthesis
cancer
liver
Liver
Doxorubicin
Cisplatin
drugs
mass spectroscopy
Crystal structure
Spectroscopy
crystal structure
Chemical analysis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Hydrogen-bonded frameworks of propylenediamine-N,N′-diacetic acid Pt(II) complexes, synthesis, structural characterization, and antitumor activity. / El-Ghamry, Hoda A.; Masaoka, Shigeyuki; Sakai, Ken.

In: Journal of Coordination Chemistry, Vol. 67, No. 6, 19.03.2014, p. 943-955.

Research output: Contribution to journalArticle

@article{c8678daa8adf4b8b9252e564832ae943,
title = "Hydrogen-bonded frameworks of propylenediamine-N,N′-diacetic acid Pt(II) complexes, synthesis, structural characterization, and antitumor activity",
abstract = "Two Pt(II) complexes of propylenediamine-N,N′-diacetic acid (H 2pdda) have been synthesized in which H2pdda is bidentate and tetradentate. The two complexes, [Pt(C7H14N 2O4)Cl2] (1) and [Pt(C7H 12N2O4)] (2), have been characterized by elemental analysis, IR, mass spectroscopy, and thermal (TGA and DTG) analysis. The crystal structure of 1 and [Pt(C7H12N 2O4)]·3H2O (2a) are reported. In vitro cytotoxic properties of 1 and 2 were evaluated against HEPG2 (liver carcinoma cell lines) and HCT116 (colon carcinoma cell lines), and were compared with the standard anticancer drugs cisplatin (cis-DDP) and doxorubicin (Dox). The obtained data indicate that the two complexes show weak cytotoxic activity against the two tested cell lines, except for 1 which revealed a relatively high activity against HEPG2. Structure-activity relationships have been interpreted.",
author = "El-Ghamry, {Hoda A.} and Shigeyuki Masaoka and Ken Sakai",
year = "2014",
month = "3",
day = "19",
doi = "10.1080/00958972.2014.900550",
language = "English",
volume = "67",
pages = "943--955",
journal = "Journal of Coordination Chemistry",
issn = "0095-8972",
publisher = "Taylor and Francis Ltd.",
number = "6",

}

TY - JOUR

T1 - Hydrogen-bonded frameworks of propylenediamine-N,N′-diacetic acid Pt(II) complexes, synthesis, structural characterization, and antitumor activity

AU - El-Ghamry, Hoda A.

AU - Masaoka, Shigeyuki

AU - Sakai, Ken

PY - 2014/3/19

Y1 - 2014/3/19

N2 - Two Pt(II) complexes of propylenediamine-N,N′-diacetic acid (H 2pdda) have been synthesized in which H2pdda is bidentate and tetradentate. The two complexes, [Pt(C7H14N 2O4)Cl2] (1) and [Pt(C7H 12N2O4)] (2), have been characterized by elemental analysis, IR, mass spectroscopy, and thermal (TGA and DTG) analysis. The crystal structure of 1 and [Pt(C7H12N 2O4)]·3H2O (2a) are reported. In vitro cytotoxic properties of 1 and 2 were evaluated against HEPG2 (liver carcinoma cell lines) and HCT116 (colon carcinoma cell lines), and were compared with the standard anticancer drugs cisplatin (cis-DDP) and doxorubicin (Dox). The obtained data indicate that the two complexes show weak cytotoxic activity against the two tested cell lines, except for 1 which revealed a relatively high activity against HEPG2. Structure-activity relationships have been interpreted.

AB - Two Pt(II) complexes of propylenediamine-N,N′-diacetic acid (H 2pdda) have been synthesized in which H2pdda is bidentate and tetradentate. The two complexes, [Pt(C7H14N 2O4)Cl2] (1) and [Pt(C7H 12N2O4)] (2), have been characterized by elemental analysis, IR, mass spectroscopy, and thermal (TGA and DTG) analysis. The crystal structure of 1 and [Pt(C7H12N 2O4)]·3H2O (2a) are reported. In vitro cytotoxic properties of 1 and 2 were evaluated against HEPG2 (liver carcinoma cell lines) and HCT116 (colon carcinoma cell lines), and were compared with the standard anticancer drugs cisplatin (cis-DDP) and doxorubicin (Dox). The obtained data indicate that the two complexes show weak cytotoxic activity against the two tested cell lines, except for 1 which revealed a relatively high activity against HEPG2. Structure-activity relationships have been interpreted.

UR - http://www.scopus.com/inward/record.url?scp=84899969451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899969451&partnerID=8YFLogxK

U2 - 10.1080/00958972.2014.900550

DO - 10.1080/00958972.2014.900550

M3 - Article

AN - SCOPUS:84899969451

VL - 67

SP - 943

EP - 955

JO - Journal of Coordination Chemistry

JF - Journal of Coordination Chemistry

SN - 0095-8972

IS - 6

ER -