Hydrogen peroxide as an endothelium-derived hyperpolarizing factor

Hiroaki Shimokawa, Tetsuya Matoba

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Vascular endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide (NO), and a yet unidentified endothelium-derived hyperpolarizing factor (EDHF). Possible candidates for EDHF include epoxyeicosatrienoic acids (EETs), endothelium-derived potassium ions (K +), and as we have recently identified, hydrogen peroxide (H 2O2). Electrical communication between endothelial and smooth muscle cells through gap junctions has also been suggested to be involved in endothelium-dependent hyperpolarization. Among the above candidates, the H2O2 hypothesis well explains the pathophysiological interactions between NO and EDHF and re-highlights the physiological roles of the reactive oxygen species (ROS) in endothelium-dependent vascular responses. This brief review summarizes our current knowledge about H2O 2 as an EDHF, with special reference to its production by the endothelium, its action on membrane potentials and its pathophysiological roles.

Original languageEnglish
Pages (from-to)543-549
Number of pages7
JournalPharmacological Research
Volume49
Issue number6
DOIs
Publication statusPublished - Jan 1 2004

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Hydrogen Peroxide
Endothelium
Vascular Endothelium
Nitric Oxide
Gap Junctions
Epoprostenol
Membrane Potentials
Smooth Muscle Myocytes
Blood Vessels
Reactive Oxygen Species
Potassium
Homeostasis
Ions
Acids

All Science Journal Classification (ASJC) codes

  • Pharmacology

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Hydrogen peroxide as an endothelium-derived hyperpolarizing factor. / Shimokawa, Hiroaki; Matoba, Tetsuya.

In: Pharmacological Research, Vol. 49, No. 6, 01.01.2004, p. 543-549.

Research output: Contribution to journalArticle

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