Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts

Atsushi Sanagawa, Hideo Nagashima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV) 2 (PIV = CO t Bu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalOrganic letters
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 4 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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