Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts

Atsushi Sanagawa, Hideo Nagashima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV) 2 (PIV = CO t Bu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalOrganic Letters
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 4 2019

Fingerprint

Nitriles
nitriles
Cyanides
Cobalt
Amines
amines
cobalt
catalysts
Catalysts
Imides
acids
Acids
imides
Carbon Monoxide
particle image velocimetry
Amides
amides
hydrolysis
Chlorides
Hydrolysis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts. / Sanagawa, Atsushi; Nagashima, Hideo.

In: Organic Letters, Vol. 21, No. 1, 04.01.2019, p. 287-291.

Research output: Contribution to journalArticle

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