Hydroxyapatite hybridized with metal oxides for biomedical applications

Akiyoshi Osaka, Eiji Fujii, Koji Kawabata, Hideyuki Yoshimatsu, Satoshi Hayakawa, Kanji Tsuru, Christian Bonhomme, Florence Babonneau

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Zn-substituted apatites with homogeneous Zn distribution in the particles (ZnΦHAp) and those with graded distribution (Zn/HAp) were prepared via a conventional wet chemical synthesis and soaking the Zn-free apatite particles in zinc nitrate solutions: X-ray photoelectron spectra of the apatites confirmed such Zn distribution. Physical and chemical properties such as particle size, specific surface area, or zeta-potential and were correlated to adsorption of β2-microglobulin (β2-MG) and bovine serum albumin (BSA). Adsorption of β2-MG on both apatites increased with the Zn content, whereas more β2-MG was adsorbed on Zn/HAp than on ZnΦHAp. The amount of BSA adsorbed on ZnΦHAp reached a maximum at about 1.5%, while it remained constant for Zn/HAp. From the results, it was suggested that Zn-substituted sites had better affinity against β2-MG and favored β2-MG adsorption. Surface charge on the particles was one of the factors to explain the suppressed adsorption of BSA by both apatites.

Original languageEnglish
Title of host publicationAdvances in Bioceramics and Biocomposites II - A Collection of Papers Presented at the 30th International Conference on Advanced Ceramics and Composites
Pages39-47
Number of pages9
Edition6
Publication statusPublished - Dec 1 2006
EventAdvances in Bioceramics and Biocomposites II - 30th International Conference on Advanced Ceramics and Composites - Cocoa Beach, FL, United States
Duration: Jan 22 2006Jan 27 2006

Publication series

NameCeramic Engineering and Science Proceedings
Number6
Volume27
ISSN (Print)0196-6219

Other

OtherAdvances in Bioceramics and Biocomposites II - 30th International Conference on Advanced Ceramics and Composites
CountryUnited States
CityCocoa Beach, FL
Period1/22/061/27/06

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All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Osaka, A., Fujii, E., Kawabata, K., Yoshimatsu, H., Hayakawa, S., Tsuru, K., ... Babonneau, F. (2006). Hydroxyapatite hybridized with metal oxides for biomedical applications. In Advances in Bioceramics and Biocomposites II - A Collection of Papers Presented at the 30th International Conference on Advanced Ceramics and Composites (6 ed., pp. 39-47). (Ceramic Engineering and Science Proceedings; Vol. 27, No. 6).