Hydroxyl radical-suppressing mechanism and efficiency of melanin-mimetic nanoparticles

Koichiro Hayashi, Atsuto Tokuda, Wataru Sakamoto

Research output: Contribution to journalArticle

Abstract

Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy.

Original languageEnglish
Article number2309
JournalInternational journal of molecular sciences
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 7 2018

Fingerprint

Melanin
melanin
Melanins
hydroxyl radicals
Hydroxyl Radical
Nanoparticles
nanoparticles
Free radicals
Liver Cirrhosis
free radicals
Free Radicals
pathogenesis
Kupffer Cells
Cytotoxicity
Ketones
ketones
Lipopolysaccharides
retarding
disorders
cells

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Hydroxyl radical-suppressing mechanism and efficiency of melanin-mimetic nanoparticles. / Hayashi, Koichiro; Tokuda, Atsuto; Sakamoto, Wataru.

In: International journal of molecular sciences, Vol. 19, No. 8, 2309, 07.08.2018.

Research output: Contribution to journalArticle

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