Hyper-IgE syndrome

Hidetoshi Takada, Akihiko Nomura, Toshiro Hara

Research output: Contribution to journalArticle

2 Citations (Scopus)


Hyperimmunoglobulin-E syndrome is one of the primary immunodeficiency with the manifestations of recurrent infections especially with Staphylococcus aureus, characteristic facies, hyperextensibility of joints, multiple bone fractures, scoliosis, and delayed shedding of the primary teeth. It is a multisystem disease of autosomal dominant inheritance. Recently, a new type of hyper-IgE syndrome with autosomal recessive inheritance was identified. Although Th1/Th2 imbalance has been suspected to be a cause of this diesease, it is not clarified yet.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalJapanese Journal of Clinical Immunology
Issue number6
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Takada, H., Nomura, A., & Hara, T. (2004). Hyper-IgE syndrome. Japanese Journal of Clinical Immunology, 27(6), 361-366. https://doi.org/10.2177/jsci.27.361