Hypercholesterolemia as a part of chronic GVHD after allogeneic stem cell transplantation

Motoko Koyama, Ken ichi Matsuoka, Yuya Kunisaki, Masami Takeuchi, Kosei Matsue

Research output: Contribution to journalArticlepeer-review

Abstract

A 45-year-old female with acute myelogenous leukemia (AML-M6) received an allogeneic stem cell transplantation from an HLA-identical sibling donor in June 2002. Prophylaxis against graft-versus-host disease (GVHD) consisted of cyclosporine (CsA) and short-term methotrexate. Acute GVHD did not occur and CsA was discontinued on day 145 after transplantation. However, soon thereafter she suffered from conjunctivitis, stomatitis and liver dysfunction with hypercholesterolemia and was diagnosed as having chronic GVHD. The liver dysfunction and hypercholesterolemia failed to improve despite the administration of CsA and prednisolone. Atrovastatin was not effective and immunosuppressive therapy for two months including ursodeoxycholic acid finally improved the jaundice and hypercholesterolemia. Although lipid metabolism analysis in this case disclosed the same findings as in other intrahepatic cholestatic liver diseases, the results show that the improvement of hypercholesterolemia in chronic GVHD needs the same treatment as chronic GVHD.

Original languageEnglish
Pages (from-to)1115-1118
Number of pages4
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume45
Issue number10
Publication statusPublished - Jan 1 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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