Abstract
Beckwith–Wiedemann syndrome (BWS) is a congenital overgrowth syndrome that is occasionally associated with hyperinsulinemic hypoglycemia (HH) in the neonatal period. Sotos syndrome (SS) and Kabuki syndrome (KS) are other malformation syndromes that may be complicated with HH, however, the detailed clinical characteristics of HH accompanied with these syndromes remain unclear. We herein conducted a nationwide questionnaire survey in Japan. We sent a primary questionnaire concerning the clinical experience for these syndromes to 347 perinatal care institutions. As a result, 222 departments or hospitals returned the questionnaires and the total numbers of BWS, SS, and KS patients were 113, 88, and 51, respectively. We sent a secondary questionnaire to 31 institutions where patients with these syndromes presented with HH during infancy. The secondary questionnaires were returned from the institutions and the numbers of patients were 16 for BWS, 9 for SS, and 3 for KS, respectively. Then, we compared the clinical characteristics of infants suffering from transient HH with and without these dysmorphic syndromes. As a result, BWS, SS, and KS patients showed significantly larger body size, lower Apgar scores, higher insulin levels at HH, and shorter durations of HH than non-dysmorphic infants with transient HH. We propose that a careful observation for the signs of HH, even if not specific to the syndromes, is important for the diagnosis of patients with BWS, SS, and KS in the postnatal period.
| Original language | English |
|---|---|
| Pages (from-to) | 360-367 |
| Number of pages | 8 |
| Journal | American Journal of Medical Genetics, Part A |
| Volume | 173 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2017 |
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All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
Cite this
Hyperinsulinemic hypoglycemia in Beckwith–Wiedemann, Sotos, and Kabuki syndromes : A nationwide survey in Japan. / Toda, Naoko; Ihara, Kenji; Kojima-Ishii, Kanako; Ochiai, Masayuki; Ohkubo, Kazuhiro; Kawamoto, Yutaka; Kohno, Yoshinori; Kumasaka, Sakae; Kawase, Akihiko; Ueno, Yasuhisa; Futatani, Takeshi; Miyazawa, Tokuo; Nagaoki, Yuko; Nakata, Setsuko; Misaki, Maiko; Arai, Hiroko; Kawai, Masahiko; Sato, Maki; Yada, Yukari; Takahashi, Nobuhiro; Komatsu, Atsushi; Maki, Kanemasa; Watabe, Shinichi; Sumida, Yutaka; Kuwashima, Makoto; Mizumoto, Hiroshi; Sato, Kazuo; Hara, Toshiro.
In: American Journal of Medical Genetics, Part A, Vol. 173, No. 2, 01.02.2017, p. 360-367.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Hyperinsulinemic hypoglycemia in Beckwith–Wiedemann, Sotos, and Kabuki syndromes
T2 - A nationwide survey in Japan
AU - Toda, Naoko
AU - Ihara, Kenji
AU - Kojima-Ishii, Kanako
AU - Ochiai, Masayuki
AU - Ohkubo, Kazuhiro
AU - Kawamoto, Yutaka
AU - Kohno, Yoshinori
AU - Kumasaka, Sakae
AU - Kawase, Akihiko
AU - Ueno, Yasuhisa
AU - Futatani, Takeshi
AU - Miyazawa, Tokuo
AU - Nagaoki, Yuko
AU - Nakata, Setsuko
AU - Misaki, Maiko
AU - Arai, Hiroko
AU - Kawai, Masahiko
AU - Sato, Maki
AU - Yada, Yukari
AU - Takahashi, Nobuhiro
AU - Komatsu, Atsushi
AU - Maki, Kanemasa
AU - Watabe, Shinichi
AU - Sumida, Yutaka
AU - Kuwashima, Makoto
AU - Mizumoto, Hiroshi
AU - Sato, Kazuo
AU - Hara, Toshiro
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Beckwith–Wiedemann syndrome (BWS) is a congenital overgrowth syndrome that is occasionally associated with hyperinsulinemic hypoglycemia (HH) in the neonatal period. Sotos syndrome (SS) and Kabuki syndrome (KS) are other malformation syndromes that may be complicated with HH, however, the detailed clinical characteristics of HH accompanied with these syndromes remain unclear. We herein conducted a nationwide questionnaire survey in Japan. We sent a primary questionnaire concerning the clinical experience for these syndromes to 347 perinatal care institutions. As a result, 222 departments or hospitals returned the questionnaires and the total numbers of BWS, SS, and KS patients were 113, 88, and 51, respectively. We sent a secondary questionnaire to 31 institutions where patients with these syndromes presented with HH during infancy. The secondary questionnaires were returned from the institutions and the numbers of patients were 16 for BWS, 9 for SS, and 3 for KS, respectively. Then, we compared the clinical characteristics of infants suffering from transient HH with and without these dysmorphic syndromes. As a result, BWS, SS, and KS patients showed significantly larger body size, lower Apgar scores, higher insulin levels at HH, and shorter durations of HH than non-dysmorphic infants with transient HH. We propose that a careful observation for the signs of HH, even if not specific to the syndromes, is important for the diagnosis of patients with BWS, SS, and KS in the postnatal period.
AB - Beckwith–Wiedemann syndrome (BWS) is a congenital overgrowth syndrome that is occasionally associated with hyperinsulinemic hypoglycemia (HH) in the neonatal period. Sotos syndrome (SS) and Kabuki syndrome (KS) are other malformation syndromes that may be complicated with HH, however, the detailed clinical characteristics of HH accompanied with these syndromes remain unclear. We herein conducted a nationwide questionnaire survey in Japan. We sent a primary questionnaire concerning the clinical experience for these syndromes to 347 perinatal care institutions. As a result, 222 departments or hospitals returned the questionnaires and the total numbers of BWS, SS, and KS patients were 113, 88, and 51, respectively. We sent a secondary questionnaire to 31 institutions where patients with these syndromes presented with HH during infancy. The secondary questionnaires were returned from the institutions and the numbers of patients were 16 for BWS, 9 for SS, and 3 for KS, respectively. Then, we compared the clinical characteristics of infants suffering from transient HH with and without these dysmorphic syndromes. As a result, BWS, SS, and KS patients showed significantly larger body size, lower Apgar scores, higher insulin levels at HH, and shorter durations of HH than non-dysmorphic infants with transient HH. We propose that a careful observation for the signs of HH, even if not specific to the syndromes, is important for the diagnosis of patients with BWS, SS, and KS in the postnatal period.
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UR - http://www.scopus.com/inward/citedby.url?scp=84998717782&partnerID=8YFLogxK
U2 - 10.1002/ajmg.a.38011
DO - 10.1002/ajmg.a.38011
M3 - Article
C2 - 28102591
AN - SCOPUS:84998717782
VL - 173
SP - 360
EP - 367
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 1552-4825
IS - 2
ER -