Hyperprolactinemia in optico-spinal multiple sclerosis

Kenji Yamasaki, Izumi Horiuchi, Motozumi Minohara, Manabu Osoegawa, Yuji Kawano, Yasumasa Ohyagi, Takeshi Yamada, Jun Ichi Kira

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objective To clarify the clinical features of MS patients with hyperprolactinemia. Subjects and Methods The serum prolactin level was measured in 67 Japanese patients (19 men and 48 women) with multiple sclerosis (MS) and in 16 patients (4 men and 12 women) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) using a two-site immunoradiometric assay. Results In the MS patients, 32 were classified as having Asian type MS showing a selective involvement of the optic nerves and spinal cord, while the other 35 were classified as having Western type MS which displayed disseminated central nervous system involvement. In women, the serum prolactin level was found to be significantly higher only in Asian type MS (mean=23.1 ng/ml, n=25) than in HAM/TSP (mean=6.9 ng/ml, n=12) (p=0.0297), while it did not differ significantly in men among the three groups. Hyperprolactinemia was significantly associated with acute relapse involving the optic nerves. All MS patients with hyperprolactinemia (7 women with Asian type MS and 2 women with Western type MS) showed recurrent opticomyelitis either throughout or in the early course of the disease, and also had a higher age of onset, a higher Expanded Disability Status Scale score, a greater visual impairment, and higher cell counts and protein contents in the cerebrospinal fluid than did the normoprolactinemic patients. Conclusion Hyperprolactinemia may be one of the characteristic features of Asian patients with MS who preferentially show the optic nerve involvement.

Original languageEnglish
Pages (from-to)296-299
Number of pages4
JournalInternal Medicine
Volume39
Issue number4
DOIs
Publication statusPublished - Apr 2000

Fingerprint

Hyperprolactinemia
Multiple Sclerosis
Optic Nerve
Tropical Spastic Paraparesis
Prolactin
Immunoradiometric Assay
Vision Disorders
Serum
Age of Onset
Cerebrospinal Fluid
Spinal Cord
Central Nervous System
Cell Count
Recurrence

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Yamasaki, K., Horiuchi, I., Minohara, M., Osoegawa, M., Kawano, Y., Ohyagi, Y., ... Kira, J. I. (2000). Hyperprolactinemia in optico-spinal multiple sclerosis. Internal Medicine, 39(4), 296-299. https://doi.org/10.2169/internalmedicine.39.296

Hyperprolactinemia in optico-spinal multiple sclerosis. / Yamasaki, Kenji; Horiuchi, Izumi; Minohara, Motozumi; Osoegawa, Manabu; Kawano, Yuji; Ohyagi, Yasumasa; Yamada, Takeshi; Kira, Jun Ichi.

In: Internal Medicine, Vol. 39, No. 4, 04.2000, p. 296-299.

Research output: Contribution to journalArticle

Yamasaki, K, Horiuchi, I, Minohara, M, Osoegawa, M, Kawano, Y, Ohyagi, Y, Yamada, T & Kira, JI 2000, 'Hyperprolactinemia in optico-spinal multiple sclerosis', Internal Medicine, vol. 39, no. 4, pp. 296-299. https://doi.org/10.2169/internalmedicine.39.296
Yamasaki K, Horiuchi I, Minohara M, Osoegawa M, Kawano Y, Ohyagi Y et al. Hyperprolactinemia in optico-spinal multiple sclerosis. Internal Medicine. 2000 Apr;39(4):296-299. https://doi.org/10.2169/internalmedicine.39.296
Yamasaki, Kenji ; Horiuchi, Izumi ; Minohara, Motozumi ; Osoegawa, Manabu ; Kawano, Yuji ; Ohyagi, Yasumasa ; Yamada, Takeshi ; Kira, Jun Ichi. / Hyperprolactinemia in optico-spinal multiple sclerosis. In: Internal Medicine. 2000 ; Vol. 39, No. 4. pp. 296-299.
@article{0d6cc34fd48342fbaa2459b7de665ea5,
title = "Hyperprolactinemia in optico-spinal multiple sclerosis",
abstract = "Objective To clarify the clinical features of MS patients with hyperprolactinemia. Subjects and Methods The serum prolactin level was measured in 67 Japanese patients (19 men and 48 women) with multiple sclerosis (MS) and in 16 patients (4 men and 12 women) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) using a two-site immunoradiometric assay. Results In the MS patients, 32 were classified as having Asian type MS showing a selective involvement of the optic nerves and spinal cord, while the other 35 were classified as having Western type MS which displayed disseminated central nervous system involvement. In women, the serum prolactin level was found to be significantly higher only in Asian type MS (mean=23.1 ng/ml, n=25) than in HAM/TSP (mean=6.9 ng/ml, n=12) (p=0.0297), while it did not differ significantly in men among the three groups. Hyperprolactinemia was significantly associated with acute relapse involving the optic nerves. All MS patients with hyperprolactinemia (7 women with Asian type MS and 2 women with Western type MS) showed recurrent opticomyelitis either throughout or in the early course of the disease, and also had a higher age of onset, a higher Expanded Disability Status Scale score, a greater visual impairment, and higher cell counts and protein contents in the cerebrospinal fluid than did the normoprolactinemic patients. Conclusion Hyperprolactinemia may be one of the characteristic features of Asian patients with MS who preferentially show the optic nerve involvement.",
author = "Kenji Yamasaki and Izumi Horiuchi and Motozumi Minohara and Manabu Osoegawa and Yuji Kawano and Yasumasa Ohyagi and Takeshi Yamada and Kira, {Jun Ichi}",
year = "2000",
month = "4",
doi = "10.2169/internalmedicine.39.296",
language = "English",
volume = "39",
pages = "296--299",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "4",

}

TY - JOUR

T1 - Hyperprolactinemia in optico-spinal multiple sclerosis

AU - Yamasaki, Kenji

AU - Horiuchi, Izumi

AU - Minohara, Motozumi

AU - Osoegawa, Manabu

AU - Kawano, Yuji

AU - Ohyagi, Yasumasa

AU - Yamada, Takeshi

AU - Kira, Jun Ichi

PY - 2000/4

Y1 - 2000/4

N2 - Objective To clarify the clinical features of MS patients with hyperprolactinemia. Subjects and Methods The serum prolactin level was measured in 67 Japanese patients (19 men and 48 women) with multiple sclerosis (MS) and in 16 patients (4 men and 12 women) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) using a two-site immunoradiometric assay. Results In the MS patients, 32 were classified as having Asian type MS showing a selective involvement of the optic nerves and spinal cord, while the other 35 were classified as having Western type MS which displayed disseminated central nervous system involvement. In women, the serum prolactin level was found to be significantly higher only in Asian type MS (mean=23.1 ng/ml, n=25) than in HAM/TSP (mean=6.9 ng/ml, n=12) (p=0.0297), while it did not differ significantly in men among the three groups. Hyperprolactinemia was significantly associated with acute relapse involving the optic nerves. All MS patients with hyperprolactinemia (7 women with Asian type MS and 2 women with Western type MS) showed recurrent opticomyelitis either throughout or in the early course of the disease, and also had a higher age of onset, a higher Expanded Disability Status Scale score, a greater visual impairment, and higher cell counts and protein contents in the cerebrospinal fluid than did the normoprolactinemic patients. Conclusion Hyperprolactinemia may be one of the characteristic features of Asian patients with MS who preferentially show the optic nerve involvement.

AB - Objective To clarify the clinical features of MS patients with hyperprolactinemia. Subjects and Methods The serum prolactin level was measured in 67 Japanese patients (19 men and 48 women) with multiple sclerosis (MS) and in 16 patients (4 men and 12 women) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) using a two-site immunoradiometric assay. Results In the MS patients, 32 were classified as having Asian type MS showing a selective involvement of the optic nerves and spinal cord, while the other 35 were classified as having Western type MS which displayed disseminated central nervous system involvement. In women, the serum prolactin level was found to be significantly higher only in Asian type MS (mean=23.1 ng/ml, n=25) than in HAM/TSP (mean=6.9 ng/ml, n=12) (p=0.0297), while it did not differ significantly in men among the three groups. Hyperprolactinemia was significantly associated with acute relapse involving the optic nerves. All MS patients with hyperprolactinemia (7 women with Asian type MS and 2 women with Western type MS) showed recurrent opticomyelitis either throughout or in the early course of the disease, and also had a higher age of onset, a higher Expanded Disability Status Scale score, a greater visual impairment, and higher cell counts and protein contents in the cerebrospinal fluid than did the normoprolactinemic patients. Conclusion Hyperprolactinemia may be one of the characteristic features of Asian patients with MS who preferentially show the optic nerve involvement.

UR - http://www.scopus.com/inward/record.url?scp=0034166955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034166955&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.39.296

DO - 10.2169/internalmedicine.39.296

M3 - Article

C2 - 10801143

AN - SCOPUS:0034166955

VL - 39

SP - 296

EP - 299

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 4

ER -