Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1

Taku Yamaguchi, Takashi Kubota, Takashi Kanematsu, Keiichi Nakayama, Masato Hirata, Tsuneyuki Yamamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In the present study, we investigated the effects of pentylenetetrazol (PTZ), a chemical convulsant that interacts with the GABA A receptor, in mice lacking the phospholipase C (PLC)-related inactive protein-1 (PRIP-1). PRIP-1 knockout mice did not develop spontaneous behavioral seizure. PRIP-1 knockout mice had markedly shorter latencies until the first clonic convulsion (CL) and tonic extensor (TE) following PTZ administration and increased incidence of convulsion compared to those in wild-type mice. Furthermore, the mortality rate by PTZ in mice lacking the PRIP-1 was also significantly increased in comparison with that in wild-type mice. These findings suggested that mice lacking the PRIP-1 were hypersensitive to PTZ-induced convulsion, and PRIP-1 might play roles in suppressing excessive excitability via interactions with the GABA A receptor.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalBrain Research
Volume1025
Issue number1-2
DOIs
Publication statusPublished - Oct 29 2004

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Pentylenetetrazole
Type C Phospholipases
Hypersensitivity
Seizures
Proteins
GABA-A Receptors
Knockout Mice
Tonic-Clonic Epilepsy
Convulsants
Mortality
Incidence

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1. / Yamaguchi, Taku; Kubota, Takashi; Kanematsu, Takashi; Nakayama, Keiichi; Hirata, Masato; Yamamoto, Tsuneyuki.

In: Brain Research, Vol. 1025, No. 1-2, 29.10.2004, p. 237-240.

Research output: Contribution to journalArticle

Yamaguchi, Taku ; Kubota, Takashi ; Kanematsu, Takashi ; Nakayama, Keiichi ; Hirata, Masato ; Yamamoto, Tsuneyuki. / Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1. In: Brain Research. 2004 ; Vol. 1025, No. 1-2. pp. 237-240.
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