TY - JOUR
T1 - Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1
AU - Yamaguchi, Taku
AU - Kubota, Takashi
AU - Kanematsu, Takashi
AU - Nakayama, Keiichi
AU - Hirata, Masato
AU - Yamamoto, Tsuneyuki
PY - 2004/10/29
Y1 - 2004/10/29
N2 - In the present study, we investigated the effects of pentylenetetrazol (PTZ), a chemical convulsant that interacts with the GABA A receptor, in mice lacking the phospholipase C (PLC)-related inactive protein-1 (PRIP-1). PRIP-1 knockout mice did not develop spontaneous behavioral seizure. PRIP-1 knockout mice had markedly shorter latencies until the first clonic convulsion (CL) and tonic extensor (TE) following PTZ administration and increased incidence of convulsion compared to those in wild-type mice. Furthermore, the mortality rate by PTZ in mice lacking the PRIP-1 was also significantly increased in comparison with that in wild-type mice. These findings suggested that mice lacking the PRIP-1 were hypersensitive to PTZ-induced convulsion, and PRIP-1 might play roles in suppressing excessive excitability via interactions with the GABA A receptor.
AB - In the present study, we investigated the effects of pentylenetetrazol (PTZ), a chemical convulsant that interacts with the GABA A receptor, in mice lacking the phospholipase C (PLC)-related inactive protein-1 (PRIP-1). PRIP-1 knockout mice did not develop spontaneous behavioral seizure. PRIP-1 knockout mice had markedly shorter latencies until the first clonic convulsion (CL) and tonic extensor (TE) following PTZ administration and increased incidence of convulsion compared to those in wild-type mice. Furthermore, the mortality rate by PTZ in mice lacking the PRIP-1 was also significantly increased in comparison with that in wild-type mice. These findings suggested that mice lacking the PRIP-1 were hypersensitive to PTZ-induced convulsion, and PRIP-1 might play roles in suppressing excessive excitability via interactions with the GABA A receptor.
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U2 - 10.1016/j.brainres.2004.08.009
DO - 10.1016/j.brainres.2004.08.009
M3 - Article
C2 - 15464766
AN - SCOPUS:5344244023
SN - 0006-8993
VL - 1025
SP - 237
EP - 240
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -