Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure

Jun Ichi Oyama, Yoshihiro Kudo, Toyoki Maeda, Koichi Node, Naoki Makino

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Balneotherapy has been shown to reduce systemic blood pressure in healthy volunteers. Hyperthermia might ameliorate the inflammatory status in heart failure through improving cardiac function. The purpose of this study was to examine the beneficial effects of balneotherapy in patients with chronic heart failure (CHF). Thirty-two patients with systolic CHF classified as New York Heart Association functional status II or III were randomized to divide either a balneotherapy group or a control group. The patients in the balneotherapy group were immersed in a hot spring at 40 C for 10 min daily for 2 weeks; the control group patients took a shower daily. The left ventricular ejection fraction (EF) and cardiothoracic ratio (CTR) were evaluated and plasma brain natriuretic peptide (BNP), high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 levels were measured. The clinical symptoms improved after 2 weeks of hot spring therapy. Although the heart rate did not change, clinical symptoms, CTR, EF, and BNP were significantly improved. Moreover, the inflammatory responses, including hsCRP, TNF-α and IL-6 decreased significantly after balneotherapy. The improvement of BNP correlates with the changes in inflammatory biomarkers. Repeated hyperthermia by bathing in a hot spring is therefore considered to improve the cardiac and inflammatory status in patients with CHF.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalHeart and Vessels
Volume28
Issue number2
DOIs
Publication statusPublished - Mar 1 2013

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Balneology
Hot Springs
Fever
Heart Failure
Cytokines
Brain Natriuretic Peptide
C-Reactive Protein
Interleukin-6
Tumor Necrosis Factor-alpha
Systolic Heart Failure
Control Groups
Interleukin-1
Stroke Volume
Healthy Volunteers
Biomarkers
Heart Rate
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure. / Oyama, Jun Ichi; Kudo, Yoshihiro; Maeda, Toyoki; Node, Koichi; Makino, Naoki.

In: Heart and Vessels, Vol. 28, No. 2, 01.03.2013, p. 173-178.

Research output: Contribution to journalArticle

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