TY - JOUR
T1 - Hypoalbuminemia, pneumococcal vaccination and the risk of community-acquired pneumonia in the elderly
T2 - A case-control study in southern Japan
AU - Washio, Masakazu
AU - Kondo, Kyoko
AU - Fukushima, Wakaba
AU - Ohfuji, Satoko
AU - Fujisawa, Nobumitsu
AU - Matsumoto, Takafumi
AU - Tashiro, Hideki
AU - Nogami, Hiroko
AU - Iwanaga, Tomoaki
AU - Nakanishi, Yoichi
AU - Kitazono, Takanari
AU - Suzuki, Kanzo
AU - Ide, Yuichiro
AU - Hirota, Yoshio
N1 - Funding Information:
This study was supported by grants for Research on Emerging and Re-emerging Infectious Diseases, Health and Labour Sciences Research Grants from the Ministry of Health, Labor and Welfare, Japan (2008-2016).
Publisher Copyright:
© 2020 Japan Health Sciences University & Japan International Cultural Exchange Foundation.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/2
Y1 - 2020/2
N2 - Objectives: Pneumonia is one of the major causes of death in the elderly. The aim of the present study was to investigate factors related to the development of community-acquired pneumonia (CAP) as well as to evaluate the preventive effect of pneumococcal vaccination on CAP in the elderly in sub-group analyses. Methods: We performed a hospital-based case-control study. Cases were 70 patients who were newly diagnosed as having CAP while 146 controls were outpatients with other diseases (not pneumonia). All participants were 65 years and older. Results: Even after controlling for age, sex and hospital, hypoalbuminemia(< 3.5 g/dl) (adjusted OR = 4.15, 95%CI = 1.76-9.80) showed an increased risk of CAP, whereas activities of daily living (ADL) was inversely associated with a risk of CAP (self-supported vs. impaired: adjusted OR = 0.45, 95%CI = 0.22-0.93). In sub-group analyses, pneumococcal vaccination showed a decreased risk among the elderly with hypoalbuminemia (Crude OR = 0.22, 95%CI = 0.06-0.86). Even after controlling for age, sex, and hospital, pneumococcal vaccination showed an odds ratio lower than the unity although it failed to show statistical significance. Conclusions: Hypoalbuminemia and impaired ability to perform ADL may increase the risk of CAP in the elderly, whereas pneumococcal vaccination may prevent CAP among the elderly with hypoalbuminemia.
AB - Objectives: Pneumonia is one of the major causes of death in the elderly. The aim of the present study was to investigate factors related to the development of community-acquired pneumonia (CAP) as well as to evaluate the preventive effect of pneumococcal vaccination on CAP in the elderly in sub-group analyses. Methods: We performed a hospital-based case-control study. Cases were 70 patients who were newly diagnosed as having CAP while 146 controls were outpatients with other diseases (not pneumonia). All participants were 65 years and older. Results: Even after controlling for age, sex and hospital, hypoalbuminemia(< 3.5 g/dl) (adjusted OR = 4.15, 95%CI = 1.76-9.80) showed an increased risk of CAP, whereas activities of daily living (ADL) was inversely associated with a risk of CAP (self-supported vs. impaired: adjusted OR = 0.45, 95%CI = 0.22-0.93). In sub-group analyses, pneumococcal vaccination showed a decreased risk among the elderly with hypoalbuminemia (Crude OR = 0.22, 95%CI = 0.06-0.86). Even after controlling for age, sex, and hospital, pneumococcal vaccination showed an odds ratio lower than the unity although it failed to show statistical significance. Conclusions: Hypoalbuminemia and impaired ability to perform ADL may increase the risk of CAP in the elderly, whereas pneumococcal vaccination may prevent CAP among the elderly with hypoalbuminemia.
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M3 - Article
AN - SCOPUS:85079465453
SN - 1341-2051
VL - 27
SP - 24
EP - 27
JO - International Medical Journal
JF - International Medical Journal
IS - 1
ER -
