Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

Eiichi Toorisaka, Hiroshige Ono, Kazuhiko Arimori, Noriho Kamiya, Masahiro Goto

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume252
Issue number1-2
DOIs
Publication statusPublished - Feb 18 2003

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Emulsions
Hypoglycemic Agents
Surface-Active Agents
Oils
Insulin
Water
Oral Administration
Glass
Membranes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion. / Toorisaka, Eiichi; Ono, Hiroshige; Arimori, Kazuhiko; Kamiya, Noriho; Goto, Masahiro.

In: International Journal of Pharmaceutics, Vol. 252, No. 1-2, 18.02.2003, p. 271-274.

Research output: Contribution to journalArticle

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