Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

Eiichi Toorisaka; Hiroshige Ono; Kazuhiko Arimori; Noriho Kamiya; Masahiro Goto

doi:10.1016/S0378-5173(02)00674-9

Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion

Eiichi Toorisaka, Hiroshige Ono, Kazuhiko Arimori, Noriho Kamiya, Masahiro Goto

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	International Journal of Pharmaceutics
Volume	252
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-5173(02)00674-9
Publication status	Published - Feb 18 2003

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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10.1016/S0378-5173(02)00674-9

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AU - Toorisaka, Eiichi

AU - Ono, Hiroshige

AU - Arimori, Kazuhiko

AU - Kamiya, Noriho

AU - Goto, Masahiro

PY - 2003/2/18

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AB - A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.

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