Abstract
A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.
| Original language | English |
|---|---|
| Pages (from-to) | 271-274 |
| Number of pages | 4 |
| Journal | International Journal of Pharmaceutics |
| Volume | 252 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Feb 18 2003 |
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All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
Cite this
Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion. / Toorisaka, Eiichi; Ono, Hiroshige; Arimori, Kazuhiko; Kamiya, Noriho; Goto, Masahiro.
In: International Journal of Pharmaceutics, Vol. 252, No. 1-2, 18.02.2003, p. 271-274.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion
AU - Toorisaka, Eiichi
AU - Ono, Hiroshige
AU - Arimori, Kazuhiko
AU - Kamiya, Noriho
AU - Goto, Masahiro
PY - 2003/2/18
Y1 - 2003/2/18
N2 - A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.
AB - A novel solid-in-oil-in-water (S/O/W) emulsion for oral administration of insulin has been developed using surfactant-coated insulin. The S/O/W emulsion prepared by a shirasu porous glass (SPG) membrane provided a sharp size distribution and was stable. Leakage of insulin from the S/O/W emulsions was not observed for several days. The S/O/W emulsion showed the hypoglycemic activity for a long period after oral administration to rats.
UR - http://www.scopus.com/inward/record.url?scp=0037452443&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037452443&partnerID=8YFLogxK
U2 - 10.1016/S0378-5173(02)00674-9
DO - 10.1016/S0378-5173(02)00674-9
M3 - Article
C2 - 12550804
AN - SCOPUS:0037452443
VL - 252
SP - 271
EP - 274
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -