Hypothalamic microdialysis of mazindol causes anorexia with increase in synaptic serotonin in rats

Nobuaki Shimizu, Sachiko Take, Tetsuro Hori, Yutaka Oomura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Brain microdialysis was used to determine if lateral hypothalamic serotonin (5-HT) is involved in the mazindol-induced anorexia in rats. Direct application of mazindol through a microdialysis membrane both significantly increased the 5-HT levels in the lateral hypothalamus and suppressed food intake by fasted rats. The increase in 5-HT concentration was dose related and the concentration of mazindol for half-maximal response was 4.6 μM. Pretreatment with methysergide, a potent 5-HT receptor-blocking agent, significantly antagonized the mazindol-induced anorexia. These results suggest that the anorectic action of mazindol might be mediated, at least in part, through serotonergic mechanisms in the hypothalamus.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalPhysiology and Behavior
Volume49
Issue number1
DOIs
Publication statusPublished - Jan 1991

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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