Hypothalamic microdialysis of mazindol causes anorexia with increase in synaptic serotonin in rats

Nobuaki Shimizu, Sachiko Take, Tetsuro Hori, Yutaka Oomura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Brain microdialysis was used to determine if lateral hypothalamic serotonin (5-HT) is involved in the mazindol-induced anorexia in rats. Direct application of mazindol through a microdialysis membrane both significantly increased the 5-HT levels in the lateral hypothalamus and suppressed food intake by fasted rats. The increase in 5-HT concentration was dose related and the concentration of mazindol for half-maximal response was 4.6 μM. Pretreatment with methysergide, a potent 5-HT receptor-blocking agent, significantly antagonized the mazindol-induced anorexia. These results suggest that the anorectic action of mazindol might be mediated, at least in part, through serotonergic mechanisms in the hypothalamus.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalPhysiology and Behavior
Volume49
Issue number1
DOIs
Publication statusPublished - Jan 1991

Fingerprint

Mazindol
Microdialysis
Anorexia
Serotonin
Lateral Hypothalamic Area
Methysergide
Appetite Depressants
Serotonin Receptors
Hypothalamus
Eating
Membranes
Brain

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Hypothalamic microdialysis of mazindol causes anorexia with increase in synaptic serotonin in rats. / Shimizu, Nobuaki; Take, Sachiko; Hori, Tetsuro; Oomura, Yutaka.

In: Physiology and Behavior, Vol. 49, No. 1, 01.1991, p. 131-134.

Research output: Contribution to journalArticle

Shimizu, Nobuaki ; Take, Sachiko ; Hori, Tetsuro ; Oomura, Yutaka. / Hypothalamic microdialysis of mazindol causes anorexia with increase in synaptic serotonin in rats. In: Physiology and Behavior. 1991 ; Vol. 49, No. 1. pp. 131-134.
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