Hypoxia-inducible adrenomedullin in colorectal cancer

Mamoru Uemura, Hirofumi Yamamoto, Ichiro Takemasa, Koshi Mimori, Tsunekazu Mizushima, Masataka Ikeda, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.

Original languageEnglish
Pages (from-to)507-514
Number of pages8
JournalAnticancer Research
Volume31
Issue number2
Publication statusPublished - Feb 2011

Fingerprint

Adrenomedullin
Colorectal Neoplasms
Hypoxia-Inducible Factor 1
Reverse Transcriptase Polymerase Chain Reaction
Vascular Endothelial Growth Factor A
Hepatocytes
Neoplasms
Hypoxia
Neoplasm Metastasis
Recurrence

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Uemura, M., Yamamoto, H., Takemasa, I., Mimori, K., Mizushima, T., Ikeda, M., ... Mori, M. (2011). Hypoxia-inducible adrenomedullin in colorectal cancer. Anticancer Research, 31(2), 507-514.

Hypoxia-inducible adrenomedullin in colorectal cancer. / Uemura, Mamoru; Yamamoto, Hirofumi; Takemasa, Ichiro; Mimori, Koshi; Mizushima, Tsunekazu; Ikeda, Masataka; Sekimoto, Mitsugu; Doki, Yuichiro; Mori, Masaki.

In: Anticancer Research, Vol. 31, No. 2, 02.2011, p. 507-514.

Research output: Contribution to journalArticle

Uemura, M, Yamamoto, H, Takemasa, I, Mimori, K, Mizushima, T, Ikeda, M, Sekimoto, M, Doki, Y & Mori, M 2011, 'Hypoxia-inducible adrenomedullin in colorectal cancer', Anticancer Research, vol. 31, no. 2, pp. 507-514.
Uemura M, Yamamoto H, Takemasa I, Mimori K, Mizushima T, Ikeda M et al. Hypoxia-inducible adrenomedullin in colorectal cancer. Anticancer Research. 2011 Feb;31(2):507-514.
Uemura, Mamoru ; Yamamoto, Hirofumi ; Takemasa, Ichiro ; Mimori, Koshi ; Mizushima, Tsunekazu ; Ikeda, Masataka ; Sekimoto, Mitsugu ; Doki, Yuichiro ; Mori, Masaki. / Hypoxia-inducible adrenomedullin in colorectal cancer. In: Anticancer Research. 2011 ; Vol. 31, No. 2. pp. 507-514.
@article{c62f9d4345fd49478ab3b4b56d10ff25,
title = "Hypoxia-inducible adrenomedullin in colorectal cancer",
abstract = "Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.",
author = "Mamoru Uemura and Hirofumi Yamamoto and Ichiro Takemasa and Koshi Mimori and Tsunekazu Mizushima and Masataka Ikeda and Mitsugu Sekimoto and Yuichiro Doki and Masaki Mori",
year = "2011",
month = "2",
language = "English",
volume = "31",
pages = "507--514",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "2",

}

TY - JOUR

T1 - Hypoxia-inducible adrenomedullin in colorectal cancer

AU - Uemura, Mamoru

AU - Yamamoto, Hirofumi

AU - Takemasa, Ichiro

AU - Mimori, Koshi

AU - Mizushima, Tsunekazu

AU - Ikeda, Masataka

AU - Sekimoto, Mitsugu

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2011/2

Y1 - 2011/2

N2 - Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.

AB - Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.

UR - http://www.scopus.com/inward/record.url?scp=79953237875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953237875&partnerID=8YFLogxK

M3 - Article

C2 - 21378331

AN - SCOPUS:79953237875

VL - 31

SP - 507

EP - 514

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 2

ER -