Hypoxia-inducible adrenomedullin in colorectal cancer

Mamoru Uemura; Hirofumi Yamamoto; Ichiro Takemasa; Koshi Mimori; Tsunekazu Mizushima; Masataka Ikeda; Mitsugu Sekimoto; Yuichiro Doki; Masaki Mori

Hypoxia-inducible adrenomedullin in colorectal cancer

Mamoru Uemura, Hirofumi Yamamoto, Ichiro Takemasa, Koshi Mimori, Tsunekazu Mizushima, Masataka Ikeda, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

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Abstract

Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.

Original language	English
Pages (from-to)	507-514
Number of pages	8
Journal	Anticancer research
Volume	31
Issue number	2
Publication status	Published - Feb 2011

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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Cite this

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title = "Hypoxia-inducible adrenomedullin in colorectal cancer",

abstract = "Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.",

author = "Mamoru Uemura and Hirofumi Yamamoto and Ichiro Takemasa and Koshi Mimori and Tsunekazu Mizushima and Masataka Ikeda and Mitsugu Sekimoto and Yuichiro Doki and Masaki Mori",

year = "2011",

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TY - JOUR

T1 - Hypoxia-inducible adrenomedullin in colorectal cancer

AU - Uemura, Mamoru

AU - Yamamoto, Hirofumi

AU - Takemasa, Ichiro

AU - Mimori, Koshi

AU - Mizushima, Tsunekazu

AU - Ikeda, Masataka

AU - Sekimoto, Mitsugu

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2011/2

Y1 - 2011/2

N2 - Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.

AB - Background: Recently, we determined several potential prognostic factors in vivo using hypoxic tumor cells from hepatic metastases of colorectal cancer (CRC). Among them, expression of adrenomedullin (ADM) was an interesting target because it is highly induced by hypoxia. Patients and Methods: To evaluate the prognostic impact of the expression of ADM, samples from a total of 373 CRC patients were analyzed by microarray (n=222), and quantitative reverse-transcriptase polymerase chain reaction (n=151). Results: ADM was a novel independent prognostic factor for CRC (p=0.027). ADM expression correlated with hypoxia-inducible factor-1 A (p<0.0001) and vascular endothelial growth factor (p<0.0001) in vivo. Conclusion: ADM expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC.

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Hypoxia-inducible adrenomedullin in colorectal cancer

Abstract

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UN SDGs

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