IκB kinase epsilon expression in adipocytes is upregulated by interaction with macrophages

Yohei Sanada, Takahiro Kumoto, Haruna Suehiro, Takafumi Yamamoto, Fusanori Nishimura, Norihisa Kato, Noriyuki Yanaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Macrophage infiltration in the adipose tissue, and the interaction with adipocytes, is well documented to be involved in fat inflammation and obesity-associated complications. In this study, we isolated IκB kinase ε (IKKε) as a key adipocyte factor that is potentially affected by interaction with macrophages in adipose tissue in vivo. We showed that IKKε mRNA expression levels in white adipose tissue were increased in both genetic and diet-induced obese mouse. Furthermore, IKKε mRNA expression was decreased by the administration of vitamin B6, an anti-inflammatory vitamin, and that IKKε expression levels in adipose tissue were closely correlated with the numbers of infiltrating macrophages. In a co-culture system, we showed that IKKaε expression in adipocytes was upregulated by interaction with activated macrophages. This study provides novel insight into IKKε, which is involved in adipose tissue inflammation during the development of obesity.

Original languageEnglish
Pages (from-to)1357-1362
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume78
Issue number8
DOIs
Publication statusPublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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