Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats

Nobuaki Egashira, Yu Goto, Ryota Takahashi, Hikari Iba, Shota Yamamoto, Takuya Watanabe, Kaori Kubota, Takehiro Kawashiri, Chise Taniguchi, Shutaro Katsurabayashi, Katsunori Iwasaki

Research output: Contribution to journalArticlepeer-review

Abstract

Oxaliplatin is a key drug used in the management of solid tumors, such as colorectal cancer; however, it causes peripheral neuropathy. In this study, we investigated the effect of ibudilast, a phosphodiesterase inhibitor, on oxaliplatin-induced mechanical allodynia and histological changes in rats. Ibudilast (7.5 mg/kg, i.p., 5 times per week) reduced mechanical allodynia and histological changes induced by oxaliplatin (4 mg/kg, i.p., twice a week). In contrast, ibudilast (0.01–10 μM) had no effect on oxaliplatin-induced tumor cytotoxicity in murine colon adenocarcinoma 26 cells. These findings suggest that ibudilast could be useful for preventing oxaliplatin-induced peripheral neuropathy in clinical settings.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalJournal of Pharmacological Sciences
Volume147
Issue number1
DOIs
Publication statusPublished - Sep 2021

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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