Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes

C. Suzuki, M. Unoki, Y. Nakamura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Defects in the activity of the PTEN gene, a tumor suppressor, are implicated in many types of cancer in humans. However, not all mediators of PTEN signaling pathways have been clarified, and, during efforts to identify such molecules, we previously induced expression of the DUSP1 and BTG1 genes by introducing exogenous PTEN into endometrial cancer cell lines. In the course of analyzing these two genes for mutations in ovarian carcinomas, we identified a novel single-nucleotide polymorphism (SNP) in the DUSP1 gene, and three novel SNPs in the BTG1 gene, and we have established their allelic frequencies in a Japanese population sample. These polymorphic sites will be useful for detecting losses of heterozygosity (LOH) in tumors and for examining latent associations between specific alleles and disease susceptibility.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalJournal of Human Genetics
Volume46
Issue number3
DOIs
Publication statusPublished - Apr 23 2001
Externally publishedYes

Fingerprint

Single Nucleotide Polymorphism
Genes
Loss of Heterozygosity
Disease Susceptibility
Endometrial Neoplasms
Tumor Suppressor Genes
Neoplasms
Alleles
Carcinoma
Cell Line
Mutation
Population

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes. / Suzuki, C.; Unoki, M.; Nakamura, Y.

In: Journal of Human Genetics, Vol. 46, No. 3, 23.04.2001, p. 155-157.

Research output: Contribution to journalArticle

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