Identification and characterization of novel dermal Thy-1 antigen-bearing dendritic cells in murine skin

Kunihiko Tamaki, Nami Yasaka, Chung Hsing Chang, Naoto Ohtake, Atsushi Saitoh, Koichiro Nakamura, Masutaka Furue

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Using immunofluorescence on dermal sheets of mouse ear, we identified novel Thy-1+ dermal dendritic cells in murine skin. These cells are resistant to topical corticosteroid treatment. The number of these dermal Thy-1+ dendritic cells is not altered with aging of the mice or with 3 d of culture. Dermal Thy-1+ dendritic cells have melanosomes in their cytoplasm; hence, phagocytic activity is likely to be present. Double immunofluorescence revealed that most of these dermal Thy-1+ dendritic cells express CD45. Furthermore, conventional immunofluorescence and confocal laser scanning microscopic findings showed that most of these Thy-1+ dermal dendritic cells express γδ and Vγ3 T-cell receptors. The relationship between these dermal Thy-1+ dendritic cells and dendritic epidermal T cells is discussed.

Original languageEnglish
Pages (from-to)571-575
Number of pages5
JournalJournal of Investigative Dermatology
Volume106
Issue number3
DOIs
Publication statusPublished - Jan 1 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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