Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure

Hirokazu Tamamura, Akio Ojida, Teppei Ogawa, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Itaru Hamachi, Nobutaka Fujii

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Several low molecular weight nonpeptide compounds having the dipicolylamine-zinc(II) complex structure were identified as potent and selective antagonists of the chemokine receptor CXCR4. These compounds showed strong inhibitory activity against CXCL12 binding to CXCR4, and the top compound exhibited significant anti-HIV activity. Zinc(II)-dipicolylamine unit-containing compounds proved to be useful and attractive lead compounds for chemotherapy of these diseases as nonpeptide CXCR4 antagonists possessing the novel scaffold structure.

Original languageEnglish
Pages (from-to)3412-3415
Number of pages4
JournalJournal of Medicinal Chemistry
Volume49
Issue number11
DOIs
Publication statusPublished - Jun 1 2006
Externally publishedYes

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Chemokine Receptors
Molecular Weight
HIV
Drug Therapy
zinc(II) dipicolylamine
Lead

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

Cite this

Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure. / Tamamura, Hirokazu; Ojida, Akio; Ogawa, Teppei; Tsutsumi, Hiroshi; Masuno, Hiroyuki; Nakashima, Hideki; Yamamoto, Naoki; Hamachi, Itaru; Fujii, Nobutaka.

In: Journal of Medicinal Chemistry, Vol. 49, No. 11, 01.06.2006, p. 3412-3415.

Research output: Contribution to journalArticle

Tamamura, Hirokazu ; Ojida, Akio ; Ogawa, Teppei ; Tsutsumi, Hiroshi ; Masuno, Hiroyuki ; Nakashima, Hideki ; Yamamoto, Naoki ; Hamachi, Itaru ; Fujii, Nobutaka. / Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure. In: Journal of Medicinal Chemistry. 2006 ; Vol. 49, No. 11. pp. 3412-3415.
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