Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons

Hiroaki Kato, Shi Chen, Hiroshi Kiyama, Ken Ikeda, Naoki Kimura, Kinichi Nakashima, Tetsuya Taga

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Abstract

In the present study, we have identified a novel gene, NDRP (for neuronal differentiation-related protein), which is predominantly expressed in developing and regenerating neurons. The predicted NDRP comprises 1,019 amino acid residues and has 6 WD repeats in the N-terminal half and multiple potential nuclear localization signals (NLSs) at the C-terminal part. This molecule shows no significant structural similarity with any other molecules in available databases. In situ hybridization and immunohistochemistry revealed the highest expression of NRDP in sensory neurons, for instance, olfactory epithelia and neural layer of retina during embryonic development, as well as in perinatal dorsal root ganglions. The expression of this gene in intact motor neurons such as in the hypoglossal nerve was undetectable but became obvious after axotomy. These results suggest that the product of this gene might be involved in the development of sensory neurons as well as the regeneration of motor neurons.

Original languageEnglish
Pages (from-to)923-932
Number of pages10
JournalJournal of biochemistry
Volume128
Issue number6
DOIs
Publication statusPublished - Jan 1 2000
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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