Identification of an epitope for T-cells correlated with antibody response to hepatitis B surface antigen in vaccinated humans

Wei Ping Min, Nobuhiro Kamikawaji, Mari Mineta, Takeshi Tana, Seizaburo Kashiwagi, Takehiko Sasazuki

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Two antigenic T-cell epitopes of HBsAg, designated HBs16-31 and HBs81-99, were identified using synthetic peptides and HBsAg-specific T-cell lines. HBs16-31 was recognized by five HBsAg-specific T-cell lines from vaccinees with both high and low antibody titers, whereas HBs81-99 was recognized by two T-cell lines derived from vaccinees with high antibody titers. The antibody titer against HBsAg was correlated significantly with the proliferation of vaccinee's PBLs in response to HBs81-99 (r = 0.47) but not to HBs16-31, suggesting that HBs81-99 plays a critical role in anti-HBs antibody production in humans vaccinated with HBsAg.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalHuman Immunology
Volume46
Issue number2
DOIs
Publication statusPublished - Apr 1 1996

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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