Identification of anti-allergic lactic acid bacteria that suppress Ca2+ influx and histamine release in human basophilic cells

Kaoru Fujii, Tsukasa Fujiki, Ayaka Koiso, Kozue Hirakawa, Makiko Yamashita, Takashi Matsumoto, Takanori Hasegawa, Fumiki Morimatsu, Yoshinori Katakura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Many anti-allergic foods or food-derived factors have so far been reported. In this study, we screened for anti-allergic lactic acid bacteria (LABs) using the human basophilic cell line, KU812F. IgE crosslinking induced Ca2+ influx and subsequent histamine release in KU812F cells. The abilities of LAB strains to suppress the increase in [Ca2+]i level triggered by IgE crosslinking and to suppress histamine release triggered by the increased [Ca2+]i level was subsequently examined. Among the LAB strains tested, five (i.e., T2101, C0102, H1001, C1103, and H0709) suppressed both the increase in [Ca2+]i and histamine release. Thus, these five LAB strains may be candidate anti-allergic LABs. Elucidation of common structures and cell content in these LAB strains may provide a molecular basis for the anti-allergic properties of specific foods and facilitate the development of novel anti-allergic foods.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalJournal of Functional Foods
Volume10
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Anti-Allergic Agents
Histamine Release
histamine
lactic acid bacteria
Lactic Acid
Bacteria
calcium
Food
cells
crosslinking
Immunoglobulin E
human cell lines
Cell Line

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Identification of anti-allergic lactic acid bacteria that suppress Ca2+ influx and histamine release in human basophilic cells. / Fujii, Kaoru; Fujiki, Tsukasa; Koiso, Ayaka; Hirakawa, Kozue; Yamashita, Makiko; Matsumoto, Takashi; Hasegawa, Takanori; Morimatsu, Fumiki; Katakura, Yoshinori.

In: Journal of Functional Foods, Vol. 10, 01.01.2014, p. 370-376.

Research output: Contribution to journalArticle

Fujii, Kaoru ; Fujiki, Tsukasa ; Koiso, Ayaka ; Hirakawa, Kozue ; Yamashita, Makiko ; Matsumoto, Takashi ; Hasegawa, Takanori ; Morimatsu, Fumiki ; Katakura, Yoshinori. / Identification of anti-allergic lactic acid bacteria that suppress Ca2+ influx and histamine release in human basophilic cells. In: Journal of Functional Foods. 2014 ; Vol. 10. pp. 370-376.
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AU - Yamashita, Makiko

AU - Matsumoto, Takashi

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