Identification of clonogenic common lymphoid progenitors in mouse bone marrow

Motonari Kondo, Irving L. Weissman, Koichi Akashi

Research output: Contribution to journalArticlepeer-review

1560 Citations (Scopus)

Abstract

The existence of a common lymphoid progenitor that can only give rise to T cells, B cells, and natural killer (NK) cells remains controversial and constitutes an important gap in the hematopoietic lineage maps. Here, we report fiat the Lin -IL-7R+Thy-1 -Sca-1(lo)c-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro. A single Lin-IL-7R+Thy-1-Sca- 1(lo)c-Kit(lo) cell could generate at least both T and B cells. These data provide direct evidence for the existence of common lymphoid progenitors in sites of early hematopoiesis.

Original languageEnglish
Pages (from-to)661-672
Number of pages12
JournalCell
Volume91
Issue number5
DOIs
Publication statusPublished - Nov 28 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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