Identification of fyn-encoded proteins in normal human blood cells

Y. Kawakami, M. Furue, T. Kawakami

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16 Citations (Scopus)

Abstract

We have previously reported that carboxyl terminal truncations of the normal human fyn gene, a member of the src subfamily, can transform immortal mouse fibroblasts to full malignancy. In search of evidence which suggests the possible activation of the human fyn gene, we have screened DNAs and RNAs from a number of human tumor cell lines. The results indicate that the fyn gene is not frequently changed grossly in the naturally occurring tumors. To establish a basis for understanding the physiological function(s) of this highly conserved gene, we have prepared specific antibodies to the fyn-encoded proteins. Using them we have shown the presence of fyn proteins in human lymphocytes and monocytes and their protein-tyrosine kinase activity.

Original languageEnglish
Pages (from-to)389-391
Number of pages3
JournalOncogene
Volume4
Issue number3
Publication statusPublished - Jan 1 1989
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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