Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion

Mio Yano, Toshihiko Imamura, Daisuke Asai, Nobutaka Kiyokawa, Kazuhiko Nakabayashi, Kenji Matsumoto, Takao Deguchi, Yoshiko Hashii, Yu ko Honda, Daiichiro Hasegawa, Yoji Sasahara, Mutsuo Ishii, Yoshiyuki Kosaka, Koji Kato, Midori Shima, Hiroki Hori, Keiko Yumura-Yagi, Junichi Hara, Megumi Oda, Keizo HoribeHitoshi Ichikawa, Atsushi Sato

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Activating tyrosine kinase mutations or cytokine receptor signalling alterations have attracted attention as therapeutic targets for high-risk paediatric acute lymphoblastic leukaemia (ALL). We identified two novel kinase fusions, OFD1-JAK2 and NCOR1-LYN, in paediatric ALL patients with IKZF1 deletion, by mRNA sequencing. The patient with CSF2RA-CRLF2 also harboured IGH-EPOR. All these patients had high-risk features, such as high initial white blood cell counts and initial poor response to prednisolone. The functional analysis of these novel fusions is on-going to determine whether these genetic alterations can be targeted by drugs.

    Original languageEnglish
    Pages (from-to)813-817
    Number of pages5
    JournalBritish Journal of Haematology
    Volume171
    Issue number5
    DOIs
    Publication statusPublished - Dec 1 2015

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    B-Lymphoid Precursor Cells
    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Phosphotransferases
    Pediatrics
    Cytokine Receptors
    Receptor Protein-Tyrosine Kinases
    Prednisolone
    Leukocyte Count
    Messenger RNA
    Mutation
    Pharmaceutical Preparations
    Therapeutics

    All Science Journal Classification (ASJC) codes

    • Hematology

    Cite this

    Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. / Yano, Mio; Imamura, Toshihiko; Asai, Daisuke; Kiyokawa, Nobutaka; Nakabayashi, Kazuhiko; Matsumoto, Kenji; Deguchi, Takao; Hashii, Yoshiko; Honda, Yu ko; Hasegawa, Daiichiro; Sasahara, Yoji; Ishii, Mutsuo; Kosaka, Yoshiyuki; Kato, Koji; Shima, Midori; Hori, Hiroki; Yumura-Yagi, Keiko; Hara, Junichi; Oda, Megumi; Horibe, Keizo; Ichikawa, Hitoshi; Sato, Atsushi.

    In: British Journal of Haematology, Vol. 171, No. 5, 01.12.2015, p. 813-817.

    Research output: Contribution to journalArticle

    Yano, M, Imamura, T, Asai, D, Kiyokawa, N, Nakabayashi, K, Matsumoto, K, Deguchi, T, Hashii, Y, Honda, YK, Hasegawa, D, Sasahara, Y, Ishii, M, Kosaka, Y, Kato, K, Shima, M, Hori, H, Yumura-Yagi, K, Hara, J, Oda, M, Horibe, K, Ichikawa, H & Sato, A 2015, 'Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion', British Journal of Haematology, vol. 171, no. 5, pp. 813-817. https://doi.org/10.1111/bjh.13757
    Yano, Mio ; Imamura, Toshihiko ; Asai, Daisuke ; Kiyokawa, Nobutaka ; Nakabayashi, Kazuhiko ; Matsumoto, Kenji ; Deguchi, Takao ; Hashii, Yoshiko ; Honda, Yu ko ; Hasegawa, Daiichiro ; Sasahara, Yoji ; Ishii, Mutsuo ; Kosaka, Yoshiyuki ; Kato, Koji ; Shima, Midori ; Hori, Hiroki ; Yumura-Yagi, Keiko ; Hara, Junichi ; Oda, Megumi ; Horibe, Keizo ; Ichikawa, Hitoshi ; Sato, Atsushi. / Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion. In: British Journal of Haematology. 2015 ; Vol. 171, No. 5. pp. 813-817.
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    AU - Deguchi, Takao

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