Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees

Toshiyuki Hayakawa, Nobuko Arisue, Toshifumi Udono, Hirohisa Hirai, Jetsumon Sattabongkot, Tomoko Toyama, Takafumi Tsuboi, Toshihiro Horii, Kazuyuki Tanabe

Research output: Contribution to journalArticle

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Abstract

It is widely believed that human malaria parasites infect only man as a natural host. However, earlier morphological observations suggest that great apes are likely to be natural reservoirs as well. To identify malaria parasites in great apes, we screened 60 chimpanzees imported into Japan. Using the sequences of small subunit rRNA and the mitochondrial genome, we identified infection of Plasmodium malariae, a human malaria parasite, in two chimpanzees that were imported about thirty years ago. The chimpanzees have been asymptomatic to the present. In Japan, indigenous malaria disappeared more than fifty years ago; and thus, it is most likely inferred that the chimpanzees were infected in Africa, and P. malariae isolates were brought into Japan from Africa with their hosts, suggesting persistence of parasites at low level for thirty years. Such a long term latent infection is a unique feature of P. malariae infection in humans. To our knowledge, this is the first to report P. malariae infection in chimpanzees and a human malaria parasite from nonhuman primates imported to a nonendemic country.

Original languageEnglish
Article numbere7412
JournalPloS one
Volume4
Issue number10
DOIs
Publication statusPublished - Oct 12 2009

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Plasmodium malariae
Pan troglodytes
malaria
Malaria
Parasites
parasites
Pongidae
Japan
infection
Hominidae
Mitochondrial Genome
Primates
Genes
Infection
ribosomal RNA

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Hayakawa, T., Arisue, N., Udono, T., Hirai, H., Sattabongkot, J., Toyama, T., ... Tanabe, K. (2009). Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees. PloS one, 4(10), [e7412]. https://doi.org/10.1371/journal.pone.0007412

Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees. / Hayakawa, Toshiyuki; Arisue, Nobuko; Udono, Toshifumi; Hirai, Hirohisa; Sattabongkot, Jetsumon; Toyama, Tomoko; Tsuboi, Takafumi; Horii, Toshihiro; Tanabe, Kazuyuki.

In: PloS one, Vol. 4, No. 10, e7412, 12.10.2009.

Research output: Contribution to journalArticle

Hayakawa, T, Arisue, N, Udono, T, Hirai, H, Sattabongkot, J, Toyama, T, Tsuboi, T, Horii, T & Tanabe, K 2009, 'Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees', PloS one, vol. 4, no. 10, e7412. https://doi.org/10.1371/journal.pone.0007412
Hayakawa, Toshiyuki ; Arisue, Nobuko ; Udono, Toshifumi ; Hirai, Hirohisa ; Sattabongkot, Jetsumon ; Toyama, Tomoko ; Tsuboi, Takafumi ; Horii, Toshihiro ; Tanabe, Kazuyuki. / Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees. In: PloS one. 2009 ; Vol. 4, No. 10.
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