Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats

Makoto Asahina, Waka Haruyama, Yasuhiro Ichida, Mai Sakamoto, Masao Sato, Katsumi Imaizumi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation cross of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed intervalspecific congenic lines and carried out expression and sequencing analyses. Here we narrowed Dihc2 to a region including 33 genes and predicted transcripts and identified RGD1309450∥edicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalJournal of Lipid Research
Volume50
Issue number1
DOIs
Publication statusPublished - Jul 9 2009

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Cell Biology

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