Identification of sur2 mutation affecting the lifespan of fission yeast

Tatsuhiro Kurauchi, Kotaro Matsui, Takafumi Shimasaki, Hokuto Ohtsuka, Satoshi Tsubouchi, Kunio Ihara, Motohiro Tani, Hirofumi Aiba

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2+ gene, which encodes a homolog of Saccharomyces cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological lifespan. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2+ gene.

Original languageEnglish
Article numberfnab070
JournalFEMS microbiology letters
Volume368
Issue number12
DOIs
Publication statusPublished - Jul 1 2021

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Genetics

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