TY - JOUR
T1 - Identification of the rate-dependent functional refractory period of the atrioventricular node in simulated atrial fibrillation
AU - Chishaki, Akiko Suyama
AU - Sunagawa, Kenji
AU - Hayashida, Kiyoshi
AU - Sugimachi, Masaru
AU - Nakamura, Motoomi
N1 - Funding Information:
From the Research Institute of Angiocardiology and Cardiovascular Kyushu University Medical School, Fukuoka, Japan. This study was supported in part by Grant-in-Aid for General Research from the Ministry of Education, Science and Culture (01570493) and Kimura Memorial Research Fund for Cardiology for publication Jan. 11, 1990; accepted Aug. 20, 1990. Reprint requests: Kenji Sunagawa, M.D., Research Institute of Angiocardi-ology and Cardiovascular Clinic, Kyushu University Medical School, 3-l-l Maidashi, Higashiku. Fukuoka 812, Japan 411126530
PY - 1991/3
Y1 - 1991/3
N2 - We continuously observed successive pairs of R-R intervals during atrial fibrillation and hypothesized that the shortest R-R interval for a given preceding R-R interval in a pair represents the functional refractory period of the atrioventricular node at that preceding interval. To test this hypothesis we simulated atrial fibrillation in 28 isolated cross-perfused canine hearts and obtained an R-R interval scatterplot by plotting the R-R intervals as a function of the immediately preceding R-R interval. This scatterplot enabled us to detect a series of the shortest R-R intervals for a wide range of preceding R-R intervals, and this allowed us to estimate the rate-dependent functional refractory period of the atrioventricular node in simulated atrial fibrillation. The estimated functional refractory periods correlated well with those measured by the conventional method (r = 0.93). We conclude that the proposed method makes it possible to estimate the rate-dependent functional refractory periods of the atrioventricular node in atrial fibrillation.
AB - We continuously observed successive pairs of R-R intervals during atrial fibrillation and hypothesized that the shortest R-R interval for a given preceding R-R interval in a pair represents the functional refractory period of the atrioventricular node at that preceding interval. To test this hypothesis we simulated atrial fibrillation in 28 isolated cross-perfused canine hearts and obtained an R-R interval scatterplot by plotting the R-R intervals as a function of the immediately preceding R-R interval. This scatterplot enabled us to detect a series of the shortest R-R intervals for a wide range of preceding R-R intervals, and this allowed us to estimate the rate-dependent functional refractory period of the atrioventricular node in simulated atrial fibrillation. The estimated functional refractory periods correlated well with those measured by the conventional method (r = 0.93). We conclude that the proposed method makes it possible to estimate the rate-dependent functional refractory periods of the atrioventricular node in atrial fibrillation.
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U2 - 10.1016/0002-8703(91)90194-M
DO - 10.1016/0002-8703(91)90194-M
M3 - Article
C2 - 2000749
AN - SCOPUS:0025978074
VL - 121
SP - 820
EP - 826
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 3 PART 1
ER -